1H-Pyrazolo[4,3-c]pyridine,4,5,6,7-tetrahydro-1-methyl-3-(trifluoromethyl)-(9CI)

Base Information

• Chemical Name: 1H-Pyrazolo[4,3-c]pyridine,4,5,6,7-tetrahydro-1-methyl-3-(trifluoromethyl)-(9CI)
• CAS No.: 794451-94-8
• Molecular Formula: C₈H₁₀F₃N₃
• Molecular Weight: 205.183
• Mol file: 794451-94-8.mol

Synonyms:1H-Pyrazolo[4,3-c]pyridine,4,5,6,7-tetrahydro-1-methyl-3-(trifluoromethyl)-(9CI);1H-PYRAZOLO[4,3-C]PYRIDINE, 4,5,6,7-TETRAHYDRO-1-METHYL-3-(TRIFLUOROMETHYL)-;3-(trifluoromethyl)-4,5,6,7-tetrahydro-1-methyl-1H-pyrazolo[4,3-c]pyridine

Chemical Property of 1H-Pyrazolo[4,3-c]pyridine,4,5,6,7-tetrahydro-1-methyl-3-(trifluoromethyl)-(9CI)

Chemical Property:

• PSA: 29.85000
• LogP: 1.41340

Purity/Quality:

97% ^*data from raw suppliers

4,5,6,7-TETRAHYDRO-1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLO-[4,3-C]-PYRIDINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazolo[4,3-c]pyridine,4,5,6,7-tetrahydro-1-methyl-3-(trifluoromethyl)-(9CI)

There total 1 articles about 1H-Pyrazolo[4,3-c]pyridine,4,5,6,7-tetrahydro-1-methyl-3-(trifluoromethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate (733757-79-4) + methylhydrazine (60-34-4) → 1-methyl-3-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine (794451-94-8) + 2-methyl-3-trifluoromethyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine (853784-42-6)

Guidance literature:

tert-butyl 4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate; methylhydrazine; Heating;

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2005.03.012

Reference yield:

1-methyl-3-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine (794451-94-8) → 3-amino-4-(2,5-difluoro-phenyl)-1-(1-methyl-3-trifluoromethyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl)-butan-1-one

Guidance literature:

Multi-step reaction with 2 steps

1: iPr₂NEt / CH₂Cl₂

2: HCl / dioxane

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2005.03.012

Reference yield:

1-methyl-3-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine (794451-94-8) + (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoic acid (486459-98-7) → [1-(2,5-difluoro-benzyl)-3-(1-methyl-3-trifluoromethyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl)-3-oxo-propyl]-carbamic acid tert-butyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2005.03.012

upstream raw materials:

tert-butyl 4-oxo-3-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

methylhydrazine

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