C₂₃H₁₉ClF₃NO₃

Base Information

Chemical Name:C₂₃H₁₉ClF₃NO₃
CAS No.:1427407-26-8
Molecular Formula:C₂₃H₁₉ClF₃NO₃
Molecular Weight:449.857
Hs Code.:

C<sub>23</sub>H<sub>19</sub>ClF<sub>3</sub>NO<sub>3</sub>

Synonyms:C₂₃H₁₉ClF₃NO₃

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Chemical Property of C₂₃H₁₉ClF₃NO₃

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Technology Process of C₂₃H₁₉ClF₃NO₃

There total 10 articles about C₂₃H₁₉ClF₃NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1427407-25-7
2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol

: 105-36-2
ethyl bromoacetate

: 1427407-26-8
C₂₃H₁₉ClF₃NO₃

Guidance literature:: 2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol; With caesium carbonate; In acetone; for 0.5h;

ethyl bromoacetate; In acetone; at 20 ℃; for 1h;

Reference yield:

: 1214382-15-6
C₁₃H₇ClF₂O

: 1427407-26-8
C₂₃H₁₉ClF₃NO₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C

2.1: borane-THF / tetrahydrofuran / 3 h / 0 - 60 °C / Inert atmosphere

3.1: caesium carbonate / acetone / 0.5 h

3.2: 1 h / 20 °C

With borane-THF; sodium hydrogencarbonate; caesium carbonate; In tetrahydrofuran; acetone;

Reference yield:

: 2267-25-6
2-chloro-4-fluoro-1-methoxy-benzene

: 1427407-26-8
C₂₃H₁₉ClF₃NO₃

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 1.5 h / -65 °C / Inert atmosphere

1.2: 0.67 h / -60 - -20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.2: 0 - 70 °C

3.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C

5.1: borane-THF / tetrahydrofuran / 3 h / 0 - 60 °C / Inert atmosphere

6.1: caesium carbonate / acetone / 0.5 h

6.2: 1 h / 20 °C

With n-butyllithium; borane-THF; oxalyl dichloride; boron tribromide; sodium hydrogencarbonate; caesium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; acetone;