rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Base Information

Chemical Name:rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
CAS No.:857680-64-9
Molecular Formula:C₂₁H₂₉FN₂O₆
Molecular Weight:424.469
Hs Code.:

Synonyms:rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

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Chemical Property of rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

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Technology Process of rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

There total 3 articles about rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 706-08-1,5153-69-5
trans-1-(4-fluorophenyl)-2-nitro-ethene

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 857680-64-9
rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -60 - -40 ℃; for 1h;

trans-1-(4-fluorophenyl)-2-nitro-ethene; In tetrahydrofuran; at -40 - 20 ℃; for 1h;
DOI:10.1055/s-2005-918454

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 857680-64-9
rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / Et₃N / dioxane; H₂O / 2 h / 0 °C

2.1: LDA / tetrahydrofuran / 1 h / -60 - -40 °C

2.2: 99 percent / tetrahydrofuran / 1 h / -40 - 20 °C

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; 2.2: Michael addition;
DOI:10.1055/s-2005-918454

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 857680-64-9
rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / Et₃N / dioxane; H₂O / 2 h / 0 °C

2.1: LDA / tetrahydrofuran / 1 h / -60 - -40 °C

2.2: 99 percent / tetrahydrofuran / 1 h / -40 - 20 °C

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; 2.2: Michael addition;
DOI:10.1055/s-2005-918454