rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester

Base Information

Chemical Name:rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester
CAS No.:876592-60-8
Molecular Formula:C₂₁H₃₁FN₂O₄
Molecular Weight:394.487
Hs Code.:

Synonyms:rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester

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Technology Process of rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester

There total 4 articles about rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 857680-64-9
rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 876592-60-8
rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester

Guidance literature:: With hydrogen; Ra-Ni; In ethanol; at 50 ℃; for 20h; under 37503 Torr;
DOI:10.1055/s-2005-918454

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 876592-60-8
rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / 1 h / -60 - -40 °C

1.2: 99 percent / tetrahydrofuran / 1 h / -40 - 20 °C

2.1: 99 percent / H₂ / Ra-Ni / ethanol / 20 h / 50 °C / 37503 Torr

With hydrogen; lithium diisopropyl amide; Ra-Ni; In tetrahydrofuran; ethanol; 1.2: Michael addition;
DOI:10.1055/s-2005-918454

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 876592-60-8
rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / Et₃N / dioxane; H₂O / 2 h / 0 °C

2.1: LDA / tetrahydrofuran / 1 h / -60 - -40 °C

2.2: 99 percent / tetrahydrofuran / 1 h / -40 - 20 °C

3.1: 99 percent / H₂ / Ra-Ni / ethanol / 20 h / 50 °C / 37503 Torr

With hydrogen; triethylamine; lithium diisopropyl amide; Ra-Ni; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 2.2: Michael addition;
DOI:10.1055/s-2005-918454