Estrone 17-Ethylene Ketal

Base Information

Chemical Name:Estrone 17-Ethylene Ketal
CAS No.:900-83-4
Molecular Formula:C₂₀H₂₆O₃
Molecular Weight:314.425
Hs Code.:
Mol file:900-83-4.mol

Synonyms:(8R,9S,13S,14S)-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2′-[1,3]dioxolan]-3-ol

Suppliers and Price of Estrone 17-Ethylene Ketal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Estrone17-EthyleneKetal
250mg
$ 140.00

Medical Isotopes, Inc.
Estrone17-EthyleneKetal
2.5 g
$ 2000.00

Total 6 raw suppliers

Chemical Property of Estrone 17-Ethylene Ketal

Chemical Property:

Solubility.:Chloroform, Dichloromethane

Purity/Quality:

99% ^*data from raw suppliers

Estrone17-EthyleneKetal ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Estrone 17-Ethylene Ketal is a Protected Estrone (E889050) used in the preparation of A-ring substituted estrogen derivatives as antitumor agents.

Technology Process of Estrone 17-Ethylene Ketal

There total 1 articles about Estrone 17-Ethylene Ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 50-28-2
estradiol

: 107-21-1
ethylene glycol

: 53-16-7
Estrone

: 900-83-4
(8R,9S,13S,14S)-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2′-[1,3]dioxolan]-3-ol

Guidance literature:: With dimethyl sulfoxide; [ReOCl₃(PPh₃)₂]; In toluene; for 5h; Heating;
DOI:10.1021/ol990755e

Reference yield: 100.0%

: 900-83-4
(8R,9S,13S,14S)-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2′-[1,3]dioxolan]-3-ol

: 74-88-4
methyl iodide

: 28336-29-0
17,17-ethylenedioxy-3-methoxyoestra-1,3,5⁽¹⁰⁾-triene

Guidance literature:: (8R,9S,13S,14S)-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2′-[1,3]dioxolan]-3-ol; With sodium hydride; In tetrahydrofuran; for 0.5h; Inert atmosphere; Reflux;

methyl iodide; In tetrahydrofuran; for 1h; Inert atmosphere;
DOI:10.1016/j.steroids.2018.11.018

Reference yield:

: 900-83-4
(8R,9S,13S,14S)-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2′-[1,3]dioxolan]-3-ol

: 362-08-3,7683-30-9
2-methoxyestrone

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 0 °C

1.2: 19.5 g / dimethylformamide / 16 h / 20 °C

2.1: sec-BuLi / tetrahydrofuran / 2 h / -78 °C

2.2: 86 percent / tetrahydrofuran / 1 h / -78 - 0 °C

3.1: Na₂HPO₄; m-chloroperbenzoic acid / CH₂Cl₂; CHCl₃ / 1 h / 20 °C

4.1: 13.8 g / NaOH / methanol / 2 h

5.1: K₂CO₃; tetrabutylammonium iodide / dimethylformamide / 72 h / 20 °C

6.1: 1.45 g / aq. HCl / tetrahydrofuran / 1 h

With hydrogenchloride; sodium hydroxide; disodium hydrogenphosphate; sec.-butyllithium; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 3.1: Baeyer-Villiger oxidation;
DOI:10.1021/jm050066a