1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole

Base Information

• Chemical Name: 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
• CAS No.: 153332-05-9
• Molecular Formula: C₁₇H₁₇N₃OS
• Molecular Weight: 311.407
• Mol file: 153332-05-9.mol

Synonyms:1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole

Chemical Property of 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole

There total 6 articles about 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

thiosemicarbazide (79-19-6) + 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one (959-33-1) → 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole (153332-05-9)

Guidance literature:

With potassium hydroxide; In ethanol; at 25 ℃; for 0.333333h; Sonication;

DOI:10.1039/c8ta07340f

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole (153332-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol; water / 20 °C

2: potassium hydroxide / ethanol / 12 h / Reflux

With potassium hydroxide; In ethanol; water;

DOI:10.1016/j.bmc.2012.01.051

Reference yield:

acetophenone (98-86-2) → 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole (153332-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol; water / 20 °C

2: potassium hydroxide / ethanol / 12 h / Reflux

With potassium hydroxide; In ethanol; water;

DOI:10.1016/j.bmc.2012.01.051

upstream raw materials:

2,3-dibromo-3-(4-methoxy-phenyl)-1-phenyl-propan-1-one of mp: 140 degree

thiosemicarbazide

3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one

4-methoxy-benzaldehyde

Downstream raw materials:

5-methoxy-2-{2-[5-(4-methoxy-phenyl)-3-phenyl-4,5-dihydro-pyrazol-1-yl]-thiazol-4-yl}-phenol

2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-4-phenylthiazole

2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

N-(4-methoxyphenyl)-2-{2-[5-(4-methoxyphenyl)-3- phenyl-4,5-dihydropyrazol-1-yl]-4- oxo- 4,5- dihydrothiazol- 5- yl}acetamide