(+)-(2R,3S)-N-{3-{[(4-methylphenyl)sulfonyl]{4-[(trifluoroacetyl)amino]butyl}amino}propyl}-3-phenyloxiranecarboxamide

Base Information

Chemical Name:(+)-(2R,3S)-N-{3-{[(4-methylphenyl)sulfonyl]{4-[(trifluoroacetyl)amino]butyl}amino}propyl}-3-phenyloxiranecarboxamide
CAS No.:623571-39-1
Molecular Formula:C₂₅H₃₀F₃N₃O₅S
Molecular Weight:541.592
Hs Code.:

Synonyms:(+)-(2R,3S)-N-{3-{[(4-methylphenyl)sulfonyl]{4-[(trifluoroacetyl)amino]butyl}amino}propyl}-3-phenyloxiranecarboxamide

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Chemical Property of (+)-(2R,3S)-N-{3-{[(4-methylphenyl)sulfonyl]{4-[(trifluoroacetyl)amino]butyl}amino}propyl}-3-phenyloxiranecarboxamide

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Technology Process of (+)-(2R,3S)-N-{3-{[(4-methylphenyl)sulfonyl]{4-[(trifluoroacetyl)amino]butyl}amino}propyl}-3-phenyloxiranecarboxamide

There total 4 articles about (+)-(2R,3S)-N-{3-{[(4-methylphenyl)sulfonyl]{4-[(trifluoroacetyl)amino]butyl}amino}propyl}-3-phenyloxiranecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 623571-36-8
potassium (-)-(2R,3S)-trans-N-(3-bromopropyl)-3-phenyloxiranecarboxamide

: 623571-06-2
2,2,2-trifluoro-N-{4-{[(4-methylphenyl)sulfonyl]amino}butyl}acetamide

: 623571-39-1
(+)-(2R,3S)-N-{3-{[(4-methylphenyl)sulfonyl]{4-[(trifluoroacetyl)amino]butyl}amino}propyl}-3-phenyloxiranecarboxamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 7h;
DOI:10.1002/hlca.200390160

Reference yield:

: 78521-64-9
N-(4-aminobutyl)-4-methyl benzenesulfonamide

: 623571-39-1
(+)-(2R,3S)-N-{3-{[(4-methylphenyl)sulfonyl]{4-[(trifluoroacetyl)amino]butyl}amino}propyl}-3-phenyloxiranecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 82.6 percent / CH₂Cl₂ / 0.42 h

2: Cs₂CO₃ / dimethylformamide / 7 h / 20 °C

With caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390160

Reference yield:

: 186179-24-8
1,1-dimethylethyl {4-{[(4-methylphenyl)sulfonyl]amino}butyl}carbamate

: 623571-39-1
(+)-(2R,3S)-N-{3-{[(4-methylphenyl)sulfonyl]{4-[(trifluoroacetyl)amino]butyl}amino}propyl}-3-phenyloxiranecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 87.9 percent / CF₃COOH / CH₂Cl₂ / 17 h / 20 °C

2: Cs₂CO₃ / dimethylformamide / 7 h / 20 °C

With caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390160