[2-(3-Fluoro-4-methoxy-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine

Base Information

• Chemical Name: [2-(3-Fluoro-4-methoxy-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine
• CAS No.: 77445-38-6
• Molecular Formula: C₁₈H₁₉FN₂O
• Molecular Weight: 298.36
• Mol file: 77445-38-6.mol

Synonyms:[2-(3-Fluoro-4-methoxy-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine

Chemical Property of [2-(3-Fluoro-4-methoxy-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [2-(3-Fluoro-4-methoxy-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine

There total 2 articles about [2-(3-Fluoro-4-methoxy-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(3'-fluoro-4'-methoxyphenyl)-1H-indole (347-09-1) + dimethyl amine (124-40-3) → [2-(3-Fluoro-4-methoxy-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine (77445-38-6)

Guidance literature:

In acetic acid; Ambient temperature;

DOI:10.1007/BF00903661

Reference yield:

N-[1-(3-Fluoro-4-methoxy-phenyl)-eth-(E)-ylidene]-N'-phenyl-hydrazine → [2-(3-Fluoro-4-methoxy-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine (77445-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / polyphosphoric acid

2: 28 percent / acetic acid / Ambient temperature

With PPA; In acetic acid;

DOI:10.1007/BF00903661

Reference yield:

[2-(3-Fluoro-4-methoxy-phenyl)-1H-indol-3-ylmethyl]-dimethyl-amine (77445-38-6) + malonic acid dimethyl ester (108-59-8) → C21H20FNO5

Guidance literature:

With propynoic acid ethyl ester; In diethyl ether; at 20 ℃;

DOI:10.1039/d1gc02713a

upstream raw materials:

formaldehyd

2-(3'-fluoro-4'-methoxyphenyl)-1H-indole

dimethyl amine