2-(4-fluorophenyl)-2-oxoethyl methanesulfonate

Base Information

• Chemical Name: 2-(4-fluorophenyl)-2-oxoethyl methanesulfonate
• CAS No.: 1023922-09-9
• Molecular Formula: C₉H₉FO₄S
• Molecular Weight: 232.232
• Mol file: 1023922-09-9.mol

Synonyms:2-(4-fluorophenyl)-2-oxoethyl methanesulfonate

Chemical Property of 2-(4-fluorophenyl)-2-oxoethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(4-fluorophenyl)-2-oxoethyl methanesulfonate

There total 2 articles about 2-(4-fluorophenyl)-2-oxoethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-ethynyl-4-fluorobenzene (766-98-3) + methanesulfonic acid (75-75-2,98527-29-8) + acetic acid (64-19-7,77671-22-8) → 2-(4-fluorophenyl)-2-oxoethyl methanesulfonate (1023922-09-9) + α-acetoxy-4-fluoroacetophenone (366-78-9)

Guidance literature:

With 8-methylquinoline 1-oxide; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); at 20 ℃; for 8h;

DOI:10.1055/s-0033-1338513

Reference yield: 74.0%

1-ethynyl-4-fluorobenzene (766-98-3) + methanesulfonic acid (75-75-2,98527-29-8) → 2-(4-fluorophenyl)-2-oxoethyl methanesulfonate (1023922-09-9)

Guidance literature:

With 3,5-dicholoropyridine N-oxide; (Cy₃P)AuNTf₂; In chlorobenzene; at 20 ℃; for 8h;

DOI:10.1055/s-0033-1339337

Reference yield: 95.0%

2-(4-fluorophenyl)-2-oxoethyl methanesulfonate (1023922-09-9) → (S)-1-(4-fluorophenyl)-2-(methanesulfonyloxy)ethanol (1023921-46-1)

Guidance literature:

With formic acid; triethylamine hydrochloride; triethylamine; RhCl[(R,R)-TsDPEN](C₅Me₅); In ethyl acetate; at 20 ℃; for 0.666667h;

upstream raw materials:

1-ethynyl-4-fluorobenzene

methanesulfonic acid

acetic acid

Downstream raw materials:

(R)-1-(4-fluorophenyl)-2-(methanesulfonyloxy)ethanol

(S)-1-(4-fluorophenyl)-2-(methanesulfonyloxy)ethanol