366-78-9

Basic information

• Product Name: 2-(4-fluorophenyl)-2-oxoethyl acetate
• Synonyms: 2-(4-fluorophenyl)-2-oxoethyl acetate
• CAS NO: 366-78-9
• Molecular Formula: C₁₀H₉FO₃
• Molecular Weight: 196.18
• Mol File: 366-78-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 52-54°
• Boiling Point: 284°C at 760 mmHg
• Flash Point: 121.7°C
• Appearance: /
• Density: 1.213g/cm³
• Vapor Pressure: 0.00305mmHg at 25°C
• Refractive Index: 1.497
• CAS DataBase Reference: 2-(4-fluorophenyl)-2-oxoethyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-2-oxoethyl acetate(366-78-9)
• EPA Substance Registry System: 2-(4-fluorophenyl)-2-oxoethyl acetate(366-78-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 366-78-9(Hazardous Substances Data)

Usage

General Description

2-(4-fluorophenyl)-2-oxoethyl acetate is a chemical compound with the molecular formula C10H9FO3. It is also known by its IUPAC name, ethyl 2-(4-fluorophenyl)-2-oxoethyl acetate. 2-(4-fluorophenyl)-2-oxoethyl acetate is commonly used in organic synthesis and chemical research as a reagent or intermediate. It is a colorless liquid with a fruity odor, and it is slightly soluble in water but highly soluble in organic solvents such as ethanol and ether. 2-(4-fluorophenyl)-2-oxoethyl acetate is known to have low acute toxicity and is generally considered to be a safe chemical to handle when used in accordance with proper safety precautions.

InChI:InChI=1/C10H9FO3/c1-7(12)14-6-10(13)8-2-4-9(11)5-3-8/h2-5H,6H2,1H3

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 64-19-7 acetic acid 
• 127-09-3 sodium acetate 
• 706-06-9 3-(4-flurophenyl)prop-2-ynoic acid 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 127-08-2 potassium acetate 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 177750-13-9 N-(1-(4-fluorophenyl)vinyl)acetamide 
• 75-75-2 methanesulfonic acid 
• 57508-48-2 carbethoxyacetamidine hydrochloride 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 352-34-1 4-fluoro-1-iodobenzene 
• 13831-31-7 Acetoxyacetyl chloride 

Downstream Products

• 403-31-6 4-fluoro-2-hydroxy-acetophenone 
• 935534-38-6 2-((tert-butyldimethylsilyl)oxy)-1-(4-fluorophenyl)ethanone 
• 1266549-11-4 (4S)-3-[(Z)-6-tert-butyldimethylsilyloxy-5-(4-fluorophenyl)hex-4-enoyl]-4-phenyl-ox azolidin-2-one 
• 1266549-14-7 [4-[(Z,1S,2R)-6-tert-butyldimethylsilyloxy-1-(4-fluoroanilino)-5-(4-fluorophenyl)-2-[ (4S)-2-oxo-4-phenyl-oxazolidine-3-carbonyl]hex-4-enyl]phenyl] benzoate 
• 1266548-94-0 (3R,4S)-3-[(Z)-4-acetoxy-3-(4-fluorophenyl)-but-2-enyl]-4-(4-benzoyloxyphenyl)-1-( 4-fluorophenyl)azetidin-2-one 
• 1266548-97-3 ethyl (Z)-4-tert-butyldimethylsilyloxy-3-(4-fluorophenyl) but-2-enoate 
• 1266548-98-4 ethyl (E)-4-tert-butyldimethylsilyloxy-3-(4-fluorophenyl) but-2-enoate 
• 1266548-99-5 (Z)-4-tert-butyldimethylsilyloxy-3-(4-fluorophenyl)but-2-en-1-ol 
• 1266549-01-2 tert-butyl-[(Z)-4-chloro-2-(4-fluorophenyl)but-2-enoxy]-dimethyl-silane 
• 1266549-03-4 dimethyl 2-[(Z)-4-tert-butyldimethylsilyloxy-3-(4-fluorophenyl)but-2-enyl]propanedioate 
• 1266549-05-6 (Z)-6-tert-butyldimethylsilyloxy-5-(4-fluorophenyl)-2-methoxycarbonyl-hex-4-enoic acid 
• 1266549-07-8 methyl (Z)-6-tert-butyldimethylsilyloxy-5-(4-fluorophenyl)hex-4-enoate 
• 1266549-09-0 (Z)-6-tert-butyldimethylsilyloxy-5-(4-fluorophenyl)hex-4-enoic acid 
• 1266549-16-9 (3R,4S)-4-(4-benzoyloxyphenyl)-1-(4-fluorophenyl)-3-[(Z)-3-(4-fluorophenyl)-4-tert-butyldimethylsilyloxy-but-2-enyl]azetidin-2-one 

Relevant articles and documents

Decarboxylative Oxyacyloxylation of Propiolic Acids: Construction of Alkynyl-Containing α-Acyloxy Ketones

Novel decarboxylative oxyacyloxylation of propiolic acids has been developed. This reaction provides an efficient access to alkynyl-containing α-acyloxy ketones from readily available starting materials and exhibits significant functional group tolerance. Furthermore, oxyacyloxylation of terminal alkynes and aliphatic propiolic acids was also developed. A possible reaction mechanism is proposed based on mechanistic studies.

PhI(OAc)2-promoted umpolung acetoxylation of enamides for the synthesis of α-acetoxy ketones

Umpolung is a fundamental concept in organic chemistry, which provides an alternative strategy for the synthesis of target compounds which were not easily accessible by conventional methods. Herein, a mild and efficient PhI(OAc)2-promoted umpolung acetoxylation reactions of enamides was developed for the synthesis of α-acetoxy ketones. The reaction tolerates a wide range of functional groups and affords α-acetoxy ketones in good to excellent yields. PhI(OAc)2 serves as a source of acetoxy in the reaction.

Iron-Catalyzed Dioxygenation of Alkenes and Terminal Alkynes by using (Diacetoxyiodo)benzene as Oxidant

An iron-catalyzed syn-diacetoxylation of alkenes and 1,2-oxyacetoxylation of terminal alkynes has been developed using (diacetoxyiodo)benzene as oxidant. A broad range of internal and terminal alkenes, including electron-rich as well as electron-deficient alkenes, gave the desired products in good to excellent yields with high diastereoselectivity (up to >99:1 dr). In addition the high catalytic activity of iron catalysis for the 1,2-oxyacetoxylation of terminal alkynes is also reported. The roles of catalyst, oxidant and other reaction parameters were evaluated for activation of the unsaturated bond.