biphenyl-4-carboxylic acid [(4-fluoro-3-nitrophenylcarbamoyl)-methyl]-methyl-amide

Base Information

• Chemical Name: biphenyl-4-carboxylic acid [(4-fluoro-3-nitrophenylcarbamoyl)-methyl]-methyl-amide
• CAS No.: 1056476-97-1
• Molecular Formula: C₂₂H₁₈FN₃O₄
• Molecular Weight: 407.401
• Mol file: 1056476-97-1.mol

Synonyms:biphenyl-4-carboxylic acid [(4-fluoro-3-nitrophenylcarbamoyl)-methyl]-methyl-amide

Chemical Property of biphenyl-4-carboxylic acid [(4-fluoro-3-nitrophenylcarbamoyl)-methyl]-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of biphenyl-4-carboxylic acid [(4-fluoro-3-nitrophenylcarbamoyl)-methyl]-methyl-amide

There total 1 articles about biphenyl-4-carboxylic acid [(4-fluoro-3-nitrophenylcarbamoyl)-methyl]-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-fluoro-4-isocyano-2-nitrobenzene (1056476-96-0) + methylamine (74-89-5) + biphenyl-4-carboxylic acid (92-92-2) → biphenyl-4-carboxylic acid [(4-fluoro-3-nitrophenylcarbamoyl)-methyl]-methyl-amide (1056476-97-1)

Guidance literature:

In methanol; at 20 ℃; for 48h;

DOI:10.1016/j.bmcl.2008.05.096

Reference yield: 48.0%

Thiomorpholin (123-90-0) + biphenyl-4-carboxylic acid [(4-fluoro-3-nitrophenylcarbamoyl)-methyl]-methyl-amide (1056476-97-1) → biphenyl-4-carboxylic acid methyl-[(3-nitro-4-thiomorpholin-4-yl-phenyl-carbamoyl)-methyl]-amide (1056476-98-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1016/j.bmcl.2008.05.096

Reference yield:

piperidine (110-89-4) + biphenyl-4-carboxylic acid [(4-fluoro-3-nitrophenylcarbamoyl)-methyl]-methyl-amide (1056476-97-1) → C27H28N4O4 (1056476-99-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2008.05.096

upstream raw materials:

formaldehyd

1-fluoro-4-isocyano-2-nitrobenzene

methylamine

biphenyl-4-carboxylic acid

Downstream raw materials:

C₂₇H₂₈N₄O₄

biphenyl-4-carboxylic acid methyl-[(3-nitro-4-thiomorpholin-4-yl-phenyl-carbamoyl)-methyl]-amide

C₃₂H₃₄N₄O₄