Benzoesaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester

Base Information

• Chemical Name: Benzoesaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester
• CAS No.: 86547-27-5
• Molecular Formula: C₁₅H₂₀O₄
• Molecular Weight: 264.321
• Mol file: 86547-27-5.mol

Synonyms:Benzoesaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester

Chemical Property of Benzoesaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoesaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester

There total 5 articles about Benzoesaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

Benzoesaeure-<(2S)-2,3-dihydroxy-3-methylbutyl>ester (86547-26-4) → Benzoesaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester (86547-27-5)

Guidance literature:

With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 72h;

Reference yield:

2-<(S)-2,2-dimethyl-1,3-dioxolane-4-yl>-2-propanol (86562-71-2) → Benzoesaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester (86547-27-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 g / acetic acid / 1.5 h / 60 - 65 °C

2: 84.5 percent / pyridine / 24 h / 4 °C

3: 1.) p-toluenesulfonic acid; 2.) triethylamine / 1.) acetone, r.t., 13 h

With toluene-4-sulfonic acid; triethylamine; In pyridine; acetic acid;

DOI:10.1002/hlca.19830660314

Reference yield:

S(-)methyl-3 butanetriol-1,2,3 (86562-72-3) → Benzoesaeure-<((4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl>ester (86547-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84.5 percent / pyridine / 24 h / 4 °C

2: 1.) p-toluenesulfonic acid; 2.) triethylamine / 1.) acetone, r.t., 13 h

With toluene-4-sulfonic acid; triethylamine; In pyridine;

DOI:10.1002/hlca.19830660314

upstream raw materials:

2,2-dimethoxy-propane

Benzoesaeure-<(2S)-2,3-dihydroxy-3-methylbutyl>ester

S(-)methyl-3 butanetriol-1,2,3

2-<(S)-2,2-dimethyl-1,3-dioxolane-4-yl>-2-propanol

Downstream raw materials:

3-chloro-5-{[6-chloro-2-fluoro-3-({5-[2-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

3-chloro-5-[(6-chloro-3-{[5-(6-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-2-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile

3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-1,3-thiazol-5-yl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile