3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

Base Information

• Chemical Name: 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid
• CAS No.: 4402-78-2
• Molecular Formula: C₁₁H₇Cl₂NO₃
• Molecular Weight: 272.087
• Mol file: 4402-78-2.mol

Synonyms:3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

Chemical Property of 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

There total 4 articles about 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (100726-70-3) → 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4402-78-2)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃;

DOI:10.1080/10426507.2017.1393423

Reference yield:

2,4-dichloro-N-hydroxybenzenecarboximidoyl chloride (29203-60-9) → 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4402-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol

2: methanol. NaOH

With methanol; sodium hydroxide;

Reference yield:

3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid methyl ester (4402-77-1) → 3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (4402-78-2)

Guidance literature:

With potassium hydroxide; In ethanol;

DOI:10.1039/jr9650005976

upstream raw materials:

3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester

3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid methyl ester

2,4-dichloro-N-hydroxybenzenecarboximidoyl chloride

2,4-dichlorobenzaldoxime

Downstream raw materials:

3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid amide