Propanenitrile, 2-[[(4-methoxyphenyl)methyl]amino]- (9CI)

Base Information

• Chemical Name: Propanenitrile, 2-[[(4-methoxyphenyl)methyl]amino]- (9CI)
• CAS No.: 777801-61-3
• Molecular Formula: C11H14 N2 O
• Molecular Weight: 190.24166
• Mol file: 777801-61-3.mol

Synonyms:Propanenitrile, 2-[[(4-methoxyphenyl)methyl]amino]- (9CI)

Chemical Property of Propanenitrile, 2-[[(4-methoxyphenyl)methyl]amino]- (9CI)

Chemical Property:

• PSA: 45.05000
• LogP: 2.08778

Purity/Quality:

99% ^*data from raw suppliers

2-([(4-METHOXYPHENYL)METHYL]AMINO)PROPANENITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanenitrile, 2-[[(4-methoxyphenyl)methyl]amino]- (9CI)

There total 2 articles about Propanenitrile, 2-[[(4-methoxyphenyl)methyl]amino]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium cyanide (773837-37-9) + acetaldehyde (75-07-0,9002-91-9) + 4-methoxy-benzylamine (2393-23-9) → 2-[(4-methoxybenzyl)amino]propionitrile (777801-61-3)

Guidance literature:

acetaldehyde; With sodium hydrogensulfite; In water; Inert atmosphere;

4-methoxy-benzylamine; In methanol; water; at 60 ℃;

sodium cyanide; In methanol; water; at 60 ℃;

DOI:10.1071/CH08376

Reference yield:

potassium cyanide (151-50-8) + acetaldehyde (75-07-0,9002-91-9) + 4-methoxy-benzylamine (2393-23-9) → 2-[(4-methoxybenzyl)amino]propionitrile (777801-61-3)

Guidance literature:

DOI:10.1016/j.tet.2004.09.054

Reference yield: 45.0%

oxalyl dichloride (79-37-8) + 2-[(4-methoxybenzyl)amino]propionitrile (777801-61-3) → 1-(4-methoxybenzyl)-3,5-dichloro-6-methyl-pyrazine-2(1H)-one (595581-85-4)

Guidance literature:

With triethylamine hydrochloride; In chlorobenzene; at 20 ℃; for 48h;

DOI:10.1002/ejoc.200200652

upstream raw materials:

potassium cyanide

acetaldehyde

4-methoxy-benzylamine

sodium cyanide

Downstream raw materials:

1-(4-methoxybenzyl)-3,5-dichloro-6-methyl-pyrazine-2(1H)-one

5-chloro-3-isopropyl-1-(4-methoxybenzyl)-6-methyl-2(1H)-pyrazinone

5-chloro-1-(4-methoxybenzyl)-3,6-dimethyl-2(1H)-pyrazinone

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