tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate

Base Information

Chemical Name:tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate
CAS No.:1357159-29-5
Molecular Formula:C₂₆H₂₉N₃O₂
Molecular Weight:415.535
Hs Code.:

Synonyms:tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate

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Chemical Property of tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate

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Technology Process of tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate

There total 5 articles about tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1357159-28-4
tert-butyl 1-(4-(6-amino-3-chloropyridin-2-yl)phenyl)cyclobutylcarbamate

: 98-80-6
phenylboronic acid

: 1357159-29-5
tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 110 - 130 ℃; for 2.5h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm201394e

Reference yield:

: 1192814-45-1
5,6-dichloropyridin-2-amine

: 1357159-29-5
tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 72 h / 100 °C / Inert atmosphere; Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 2.5 h / 110 - 130 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; 1: Suzuki coupling / 2: Suzuki coupling;
DOI:10.1021/jm201394e

Reference yield:

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1357159-29-5
tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 72 h / 100 °C / Inert atmosphere; Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 2.5 h / 110 - 130 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; 1: Suzuki coupling / 2: Suzuki coupling;
DOI:10.1021/jm201394e