N-(5,6-Dichloropyridin-2-yl)pivalamide

Base Information

Chemical Name:N-(5,6-Dichloropyridin-2-yl)pivalamide
CAS No.:1192814-44-0
Molecular Formula:C10H12Cl2N2O
Molecular Weight:247.124
Hs Code.:
Mol file:1192814-44-0.mol

Synonyms:N-(5,6-Dichloropyridin-2-yl)pivalamide;1192814-44-0;SCHEMBL558665;MTIALXJECNTTKZ-UHFFFAOYSA-N

Suppliers and Price of N-(5,6-Dichloropyridin-2-yl)pivalamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of N-(5,6-Dichloropyridin-2-yl)pivalamide

Chemical Property:

PSA：41.99000
LogP:3.44600
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:246.0326684
Heavy Atom Count:15
Complexity:240

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)C(=O)NC1=NC(=C(C=C1)Cl)Cl

Technology Process of N-(5,6-Dichloropyridin-2-yl)pivalamide

There total 1 articles about N-(5,6-Dichloropyridin-2-yl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 45644-21-1
6-chloropyridin-2-amine

: 3282-30-2
pivaloyl chloride

: 1192814-44-0
N-(5,6-dichloropyridin-2-yl)pivalamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 h / 20 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 16 h / 100 °C

With N-chloro-succinimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bioorg.2020.103580

Reference yield: 100.0%

: 1192814-44-0
N-(5,6-dichloropyridin-2-yl)pivalamide

: 1192814-45-1
5,6-dichloropyridin-2-amine

Guidance literature:: With hydrogenchloride; In ethanol; water; at 90 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm201394e

Reference yield:

: 1192814-44-0
N-(5,6-dichloropyridin-2-yl)pivalamide

: N-benzyl-5,6-dichloro-1-(β-D-ribofuranosyl)-1H-imidazo[4,5-b]pyridin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water; ethanol / 2 h / Reflux

2.1: nitric acid; sulfuric acid / 0.75 h / 20 °C

3.1: hydrogenchloride; tin(II) chloride dihdyrate / 0.67 h / 60 °C

4.1: tetrahydrofuran / 36 h / Reflux; Inert atmosphere

4.2: 0.67 h / Reflux

5.1: acetonitrile / 2 h / Reflux

5.2: 3 h / 0 °C / Reflux

6.1: ammonia / methanol / 18 h

With hydrogenchloride; tin(II) chloride dihdyrate; sulfuric acid; ammonia; nitric acid; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;
DOI:10.3390/molecules25194531