methyl 2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylate

Base Information

Chemical Name:methyl 2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylate
CAS No.:1356000-16-2
Molecular Formula:C₃₀H₃₁N₃O₄
Molecular Weight:497.594
Hs Code.:

Synonyms:methyl 2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylate

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Chemical Property of methyl 2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylate

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Technology Process of methyl 2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylate

There total 4 articles about methyl 2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 6937-03-7
methyl 2-aminoisonicotinate

: 1355999-71-1
tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1356000-16-2
methyl 2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm201394e

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1356000-16-2
methyl 2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium perbromide hydrobromide / tetrahydrofuran / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / ethanol / 4 h / Molecular sieve; Reflux

With pyridinium perbromide hydrobromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol;

Reference yield:

: 1032349-97-5
tert-butyl[1-(4-cyanophenyl)cyclobutyl]carbamate

: 1356000-16-2
methyl 2-(4-(1-(tert-butoxycarbonylamino)cyclobutyl)phenyl)-3-phenylimidazo[1,2-a]pyridine-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / -78 - 25 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

With pyridinium hydrobromide perbromide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm201394e