furo[2,3-c]pyridine-2-carboxylic acid 4-(tetrahydropyran-4-ylsulfamoyl)benzylamide

Base Information

Chemical Name:furo[2,3-c]pyridine-2-carboxylic acid 4-(tetrahydropyran-4-ylsulfamoyl)benzylamide
CAS No.:1454284-57-1
Molecular Formula:C₂₀H₂₁N₃O₅S
Molecular Weight:415.47
Hs Code.:

Synonyms:furo[2,3-c]pyridine-2-carboxylic acid 4-(tetrahydropyran-4-ylsulfamoyl)benzylamide

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Chemical Property of furo[2,3-c]pyridine-2-carboxylic acid 4-(tetrahydropyran-4-ylsulfamoyl)benzylamide

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Technology Process of furo[2,3-c]pyridine-2-carboxylic acid 4-(tetrahydropyran-4-ylsulfamoyl)benzylamide

There total 10 articles about furo[2,3-c]pyridine-2-carboxylic acid 4-(tetrahydropyran-4-ylsulfamoyl)benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1153229-66-3
4-aminomethyl-N-(tetrahydro-pyran-4-yl)benzenesulfonamide

: 112372-15-3
furo<2,3-c>pyridine-2-carboxylic acid

: 1454284-57-1
furo[2,3-c]pyridine-2-carboxylic acid 4-(tetrahydropyran-4-ylsulfamoyl)benzylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

Reference yield:

: 927804-63-5
ethyl 3-(((trifluoromethyl) sulfonyl)oxy)furo[2,3-c]pyridine-2-carboxylate

: 1454284-57-1
furo[2,3-c]pyridine-2-carboxylic acid 4-(tetrahydropyran-4-ylsulfamoyl)benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; triethylamine; hydrogen / ethanol / 16 h / 760.05 Torr

2: potassium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 10 h / 20 °C

With palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 106531-50-4
Ethyl 3-Hydroxyfuro<2,3-c>pyridine-2-carboxylate

: 1454284-57-1
furo[2,3-c]pyridine-2-carboxylic acid 4-(tetrahydropyran-4-ylsulfamoyl)benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 16 h / 0 - 20 °C

2: palladium 10% on activated carbon; triethylamine; hydrogen / ethanol / 16 h / 760.05 Torr

3: potassium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 10 h / 20 °C

With pyridine; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;