Technology Process of (E)-6-(3-oxo-3-(3-phenoxyazetidin-1-yl)prop-1-en-1-yl)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
There total 10 articles about (E)-6-(3-oxo-3-(3-phenoxyazetidin-1-yl)prop-1-en-1-yl)-3,4-dihydro-1,8-naphthyridin-2(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 16h;
DOI:10.1016/j.ejmech.2014.07.036
- Guidance literature:
-
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: bromine / acetic acid / 20 °C
2.1: hydrogen bromide / water / Reflux
3.1: sodium methylate / methanol / 0.75 h / 20 °C
3.2: 20 °C
4.1: sodium hydroxide / methanol / 4 h / 20 °C / Reflux
4.2: 20 °C / Reflux
5.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide; propiononitrile / 110 °C / Inert atmosphere
6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
6.2: 0.17 h / 20 °C
7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
With
hydrogen bromide; bromine; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; sodium hydroxide;
palladium diacetate;
In
methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; propiononitrile;