2-ethoxy-1,1,1-trifluoro-2,3-bistrimethylsiloxy-3-phenylpropane

Base Information

• Chemical Name: 2-ethoxy-1,1,1-trifluoro-2,3-bistrimethylsiloxy-3-phenylpropane
• CAS No.: 1364625-68-2
• Molecular Formula: C₁₇H₂₉F₃O₃Si₂
• Molecular Weight: 394.582
• Mol file: 1364625-68-2.mol

Synonyms:2-ethoxy-1,1,1-trifluoro-2,3-bistrimethylsiloxy-3-phenylpropane

Chemical Property of 2-ethoxy-1,1,1-trifluoro-2,3-bistrimethylsiloxy-3-phenylpropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethoxy-1,1,1-trifluoro-2,3-bistrimethylsiloxy-3-phenylpropane

There total 1 articles about 2-ethoxy-1,1,1-trifluoro-2,3-bistrimethylsiloxy-3-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

chloro-trimethyl-silane (75-77-4) + ethyl trifluoroacetate, (383-63-1) + benzaldehyde (100-52-7) → 1,2-bis(trimethylsiloxy)-1,2-diphenylethane (35479-44-8) + 2-ethoxy-1,1,1-trifluoro-2,3-bistrimethylsiloxy-3-phenylpropane (1364625-68-2)

Guidance literature:

chloro-trimethyl-silane; ethyl trifluoroacetate,; With magnesium; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.5h; Inert atmosphere;

benzaldehyde; In 1-methyl-pyrrolidin-2-one; at -15 ℃; Solvent; Temperature; Inert atmosphere;

DOI:10.1016/j.tet.2014.02.016

Reference yield: 67.0%

2-ethoxy-1,1,1-trifluoro-2,3-bistrimethylsiloxy-3-phenylpropane (1364625-68-2) → rac-3,3,3-trifluoro-2-hydroxy-1-phenylpropan-1-one (322-01-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 5 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2014.02.016

upstream raw materials:

chloro-trimethyl-silane

ethyl trifluoroacetate,

benzaldehyde

Downstream raw materials:

rac-3,3,3-trifluoro-2-hydroxy-1-phenylpropan-1-one