3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanol

Base Information

• Chemical Name: 3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanol
• CAS No.: 146073-28-1
• Molecular Formula: C₁₆H₁₉NO₅S
• Molecular Weight: 337.397
• Mol file: 146073-28-1.mol

Synonyms:3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanol

Chemical Property of 3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanol

There total 1 articles about 3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,3-dioxolan-2-ylethylmagnesium bromide (37610-80-3) + 1-benzenesulfonyl-2-formylpyrrole (86688-93-9) → 3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanol (146073-28-1)

Guidance literature:

In tetrahydrofuran; at -20 ℃; for 0.166667h;

DOI:10.1248/cpb.40.2344

Reference yield: 81.0%

3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanol (146073-28-1) → 3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanone (146073-29-2)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 7h; Ambient temperature;

DOI:10.1248/cpb.40.2344

Reference yield:

3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanol (146073-28-1) → 7-hydroxy-1-(phenylsulfonyl)indole

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / MnO₂ / CH₂Cl₂ / 7 h / Ambient temperature

2: 69 percent / 6percent methanolic H₂SO₄ / 3.5 h / Heating

3: 23 percent / BBr₃ / CH₂Cl₂ / 0.5 h / -50 - -40 °C

With manganese(IV) oxide; sulfuric acid; boron tribromide; In dichloromethane;

DOI:10.1248/cpb.40.2344

upstream raw materials:

1,3-dioxolan-2-ylethylmagnesium bromide

1-benzenesulfonyl-2-formylpyrrole

Downstream raw materials:

3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanone

7-(methyloxy)-1-(phenylsulfonyl)-1H-indole