4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]benzonitrile

Base Information

Chemical Name:4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]benzonitrile
CAS No.:111626-36-9
Molecular Formula:C₂₈H₂₈F₂N₂O₂
Molecular Weight:462.539
Hs Code.:

Synonyms:4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]benzonitrile

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Chemical Property of 4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]benzonitrile

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Technology Process of 4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]benzonitrile

There total 6 articles about 4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 111627-46-4
4-(3-chloropropoxy)benzonitrile

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 111626-36-9
4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]benzonitrile

Guidance literature:: With sodium carbonate; potassium iodide; In butan-1-ol; Heating;
DOI:10.1021/jm00121a022

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 111626-36-9
4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 30 percent / Na₂CO₃, KI / butan-1-ol / Heating

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol; butan-1-ol;
DOI:10.1021/jm00121a022

Reference yield:

: 111627-25-9
α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

: 111626-36-9
4-[3-[4-[bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

2: 30 percent / Na₂CO₃, KI / butan-1-ol / Heating

With hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In ethanol; butan-1-ol;
DOI:10.1021/jm00121a022