1-benzyl-5-(4-bromobenzylidene)-6-methylene-3-(toluene-4-sulfonyl)piperidin-2-one

Base Information

• Chemical Name: 1-benzyl-5-(4-bromobenzylidene)-6-methylene-3-(toluene-4-sulfonyl)piperidin-2-one
• CAS No.: 1009317-57-0
• Molecular Formula: C₂₇H₂₄BrNO₃S
• Molecular Weight: 522.462

Synonyms:1-benzyl-5-(4-bromobenzylidene)-6-methylene-3-(toluene-4-sulfonyl)piperidin-2-one

Chemical Property of 1-benzyl-5-(4-bromobenzylidene)-6-methylene-3-(toluene-4-sulfonyl)piperidin-2-one

Chemical Property:

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Technology Process of 1-benzyl-5-(4-bromobenzylidene)-6-methylene-3-(toluene-4-sulfonyl)piperidin-2-one

There total 1 articles about 1-benzyl-5-(4-bromobenzylidene)-6-methylene-3-(toluene-4-sulfonyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1-benzyl-3-(4-bromobenzylidene)-5-(toluene-4-sulfonyl)piperidine-2,6-dione + methylmagnesium bromide (75-16-1) → 1-benzyl-5-(4-bromobenzylidene)-6-methylene-3-(toluene-4-sulfonyl)piperidin-2-one (1009317-57-0)

Guidance literature:

Multistep reaction.;

DOI:10.1021/ol7030312

Reference yield: 61.0%

1-benzyl-5-(4-bromobenzylidene)-6-methylene-3-(toluene-4-sulfonyl)piperidin-2-one (1009317-57-0) + dimethyl acetylenedicarboxylate (762-42-5) → 1-benzyl-5-(4-bromophenyl)-2-oxo-3-(toluene-4-sulfonyl)-1,2-dihydroquinoline-6,7-dicarboxylic acid dimethyl ester

Guidance literature:

1-benzyl-5-(4-bromobenzylidene)-6-methylene-3-(toluene-4-sulfonyl)piperidin-2-one; dimethyl acetylenedicarboxylate; In toluene; at 80 ℃;

With N-Bromosuccinimide; sodium methylate; In tetrahydrofuran; Further stages.; Heating;

DOI:10.1021/ol7030312

Reference yield: 56.0%

1-benzyl-5-(4-bromobenzylidene)-6-methylene-3-(toluene-4-sulfonyl)piperidin-2-one (1009317-57-0) + propynoic acid ethyl ester (623-47-2) → 1-benzyl-5-(4-bromophenyl)-2-oxo-3-(toluene-4-sulfonyl)-1,2-dihydroquinoline-6-carboxylic acid ethyl ester

Guidance literature:

1-benzyl-5-(4-bromobenzylidene)-6-methylene-3-(toluene-4-sulfonyl)piperidin-2-one; propynoic acid ethyl ester; In toluene; at 80 ℃;

With N-Bromosuccinimide; sodium methylate; In tetrahydrofuran; Further stages.; Heating;

DOI:10.1021/ol7030312

upstream raw materials:

methylmagnesium bromide

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