N-{(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-enyl}-4-methoxybenzylamine

Base Information

• Chemical Name: N-{(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-enyl}-4-methoxybenzylamine
• CAS No.: 262284-59-3
• Molecular Formula: C₁₆H₂₃NO₃
• Molecular Weight: 277.364
• Mol file: 262284-59-3.mol

Synonyms:N-{(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-enyl}-4-methoxybenzylamine

Chemical Property of N-{(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-enyl}-4-methoxybenzylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-enyl}-4-methoxybenzylamine

There total 6 articles about N-{(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-enyl}-4-methoxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

[1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-(4-methoxy-benzyl)-amine (124455-21-6,124455-24-9) + vinylmagnesium chloride (3536-96-7) → N-{(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-enyl}-4-methoxybenzylamine (262284-59-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 20 ℃;

DOI:10.1002/1099-0690(200108)2001:15<2841::AID-EJOC2841>3.0.CO;2-W

Reference yield:

C14H19NO3 + vinyl magnesium bromide (1826-67-1) → N-{(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-enyl}-4-methoxybenzylamine (262284-59-3)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2013.10.038

Reference yield:

4-methoxy-benzylamine (2393-23-9) → N-{(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-enyl}-4-methoxybenzylamine (262284-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / MgSO₄ / diethyl ether / 3 h / 0 °C

2: 84 percent / diethyl ether; tetrahydrofuran / 20 °C

With magnesium sulfate; In tetrahydrofuran; diethyl ether;

DOI:10.1002/1099-0690(200108)2001:15<2841::AID-EJOC2841>3.0.CO;2-W

upstream raw materials:

[1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-(4-methoxy-benzyl)-amine

vinylmagnesium chloride

4-methoxy-benzylamine

2,3-isopropylidene-glyceraldehyde

Downstream raw materials:

N-(but-3-enyl)-N-{(1S)-1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]prop-2-enyl}-4-methoxybenzylamine