1-acetyl-5-(4-hydroxy-3-methoxyphenyl)-3-phenyl-4,5-dihydro-(1H)-pyrazole

Base Information

Chemical Name:1-acetyl-5-(4-hydroxy-3-methoxyphenyl)-3-phenyl-4,5-dihydro-(1H)-pyrazole
CAS No.:1290604-83-9
Molecular Formula:C₁₈H₁₈N₂O₃
Molecular Weight:310.353
Hs Code.:

Synonyms:1-acetyl-5-(4-hydroxy-3-methoxyphenyl)-3-phenyl-4,5-dihydro-(1H)-pyrazole

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Chemical Property of 1-acetyl-5-(4-hydroxy-3-methoxyphenyl)-3-phenyl-4,5-dihydro-(1H)-pyrazole

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Technology Process of 1-acetyl-5-(4-hydroxy-3-methoxyphenyl)-3-phenyl-4,5-dihydro-(1H)-pyrazole

There total 4 articles about 1-acetyl-5-(4-hydroxy-3-methoxyphenyl)-3-phenyl-4,5-dihydro-(1H)-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 89406-16-6
3-(4'-hydroxy-3'-methoxyphenyl)-1-phenylprop-2-ene-1-one

: 64-19-7,77671-22-8
acetic acid

: 1290604-83-9
1-acetyl-5-(4-hydroxy-3-methoxyphenyl)-3-phenyl-4,5-dihydro-(1H)-pyrazole

Guidance literature:: With hydrazine hydrate; for 4h; Reflux;
DOI:10.1016/j.bmc.2011.01.058

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 98-86-2
acetophenone

: 1290604-83-9
1-acetyl-5-(4-hydroxy-3-methoxyphenyl)-3-phenyl-4,5-dihydro-(1H)-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 15 h / 20 °C

2: hydrazine hydrate / 3 h / Reflux

With hydrazine hydrate; sodium hydroxide; In methanol; water; 1: |Claisen-Schmidt Condensation;
DOI:10.1007/s00044-011-9824-9

Reference yield:

: 98-86-2
acetophenone

: 1290604-83-9
1-acetyl-5-(4-hydroxy-3-methoxyphenyl)-3-phenyl-4,5-dihydro-(1H)-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sulfuric acid / 48 h / 5 °C

2: hydrazine hydrate / 4 h / Reflux

With sulfuric acid; hydrazine hydrate; acetic acid;
DOI:10.1007/s00044-012-0312-7