methyl (Z)-5-(tert-butyldiphenylsilyloxy)-2-(N-methyltosylamido)pent-2-enoate

Base Information

Chemical Name:methyl (Z)-5-(tert-butyldiphenylsilyloxy)-2-(N-methyltosylamido)pent-2-enoate
CAS No.:1486515-72-3
Molecular Formula:C₃₀H₃₇NO₅SSi
Molecular Weight:551.779
Hs Code.:

Synonyms:methyl (Z)-5-(tert-butyldiphenylsilyloxy)-2-(N-methyltosylamido)pent-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (Z)-5-(tert-butyldiphenylsilyloxy)-2-(N-methyltosylamido)pent-2-enoate

Chemical Property:

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Technology Process of methyl (Z)-5-(tert-butyldiphenylsilyloxy)-2-(N-methyltosylamido)pent-2-enoate

There total 6 articles about methyl (Z)-5-(tert-butyldiphenylsilyloxy)-2-(N-methyltosylamido)pent-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1486515-56-3
C₂₈H₃₄INO₃SSi

: 1486515-72-3
methyl (Z)-5-(tert-butyldiphenylsilyloxy)-2-(N-methyltosylamido)pent-2-enoate

Guidance literature:: With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane; triethylamine; at 20 ℃; for 16h;
DOI:10.1021/ol4031028

Reference yield:

: 1486515-52-9
C₄₀H₆₁NO₃SSiSn

: 1486515-72-3
methyl (Z)-5-(tert-butyldiphenylsilyloxy)-2-(N-methyltosylamido)pent-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: iodine / dichloromethane / 3 h / 0 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane; dmap; triethylamine / 16 h / 20 °C

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane; iodine; triethylamine; In dichloromethane;
DOI:10.1021/ol4031028

Reference yield:

: 1486515-49-4
N-[4-(tert-butyldiphenylsilyloxy)but-1-yn-1-yl]-N-methyltosylamide

: 1486515-72-3
methyl (Z)-5-(tert-butyldiphenylsilyloxy)-2-(N-methyltosylamido)pent-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroquinone; tris(t-butyl isocyanide)tricarbonylmolybdenum(O); carbon monoxide / tetrahydrofuran / 55 °C / Schlenk technique

2: iodine / dichloromethane / 3 h / 0 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane; dmap; triethylamine / 16 h / 20 °C

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris(t-butyl isocyanide)tricarbonylmolybdenum(O); triphenyl-arsane; carbon monoxide; iodine; triethylamine; hydroquinone; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol4031028