5-methylmercaptothiocarbonyl-4-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one

Base Information

Chemical Name:5-methylmercaptothiocarbonyl-4-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one
CAS No.:1142124-48-8
Molecular Formula:C₁₈H₁₅ClN₂OS₂
Molecular Weight:374.915
Hs Code.:

Synonyms:5-methylmercaptothiocarbonyl-4-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-methylmercaptothiocarbonyl-4-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one

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Technology Process of 5-methylmercaptothiocarbonyl-4-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one

There total 3 articles about 5-methylmercaptothiocarbonyl-4-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 20365-21-3
methyl 3-oxo-3-phenylpropanedithioate

: 57-13-6
urea

: 873-76-7
para-Chlorobenzyl alcohol

: 1142124-48-8
5-methylmercaptothiocarbonyl-4-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one

Guidance literature:: para-Chlorobenzyl alcohol; With T₃P; dimethyl sulfoxide; In ethyl acetate; at 20 ℃; Inert atmosphere; Green chemistry;

methyl 3-oxo-3-phenylpropanedithioate; urea; In ethyl acetate; at 60 - 70 ℃; Inert atmosphere; Green chemistry;
DOI:10.1246/cl.130732

Reference yield: 73.0%

: 20365-21-3
methyl 3-oxo-3-phenylpropanedithioate

: 104-88-1
4-chlorobenzaldehyde

: 57-13-6
urea

: 1142124-48-8
5-methylmercaptothiocarbonyl-4-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one

Guidance literature:: With H₂SO₄-SiO₂; In ethanol; at 80 ℃; for 3h;
DOI:10.1021/jo101572c

Reference yield:

: 98-86-2
acetophenone

: 1142124-48-8
5-methylmercaptothiocarbonyl-4-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 - 25 °C

2: SiO₂*ZnCl₂ / neat (no solvent) / 1 h / 90 °C / Green chemistry

With SiO₂*ZnCl₂; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1002/bkcs.10606