3-amino-3-[3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)phenyl]propionic acid ethyl ester hydrochloride salt

Base Information

Chemical Name:3-amino-3-[3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)phenyl]propionic acid ethyl ester hydrochloride salt
CAS No.:1541197-80-1
Molecular Formula:C₁₅H₂₀F₃NO₃*ClH
Molecular Weight:355.785
Hs Code.:

Synonyms:3-amino-3-[3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)phenyl]propionic acid ethyl ester hydrochloride salt

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Chemical Property of 3-amino-3-[3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)phenyl]propionic acid ethyl ester hydrochloride salt

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Technology Process of 3-amino-3-[3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)phenyl]propionic acid ethyl ester hydrochloride salt

There total 4 articles about 3-amino-3-[3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)phenyl]propionic acid ethyl ester hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071-46-1
hydrogen ethyl malonate

: 1541197-86-7
3-(1-hydroxy-1-methylethyl)-5-trifluoromethylbenzaldehyde

: 1541197-80-1
3-amino-3-[3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)phenyl]propionic acid ethyl ester hydrochloride salt

Guidance literature:: hydrogen ethyl malonate; 3-(1-hydroxy-1-methylethyl)-5-trifluoromethylbenzaldehyde; With ammonium formate; In ethanol; at 50 ℃; for 4h;

With hydrogenchloride; In 1,4-dioxane; ethanol; at 0 ℃; for 0.416667h;

Reference yield:

: 1541197-84-5
2-(3-trifluoromethyl-5-[1,3]dioxolan-2-ylphenyl)propan-2-ol

: 1541197-80-1
3-amino-3-[3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)phenyl]propionic acid ethyl ester hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / acetone / 4 h / 25 °C

2.1: ammonium formate / ethanol / 4 h / 50 °C

2.2: 0.42 h / 0 °C

With ammonium formate; toluene-4-sulfonic acid; In ethanol; acetone;

Reference yield:

: 1541197-82-3
2-(3-bromo-5-(trifluoromethyl)phenyl)-[1,3]dioxolane

: 1541197-80-1
3-amino-3-[3-(1-hydroxy-1-methylethyl)-5-(trifluoromethyl)phenyl]propionic acid ethyl ester hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether / 0.83 h / -78 °C

1.2: 1 h / -78 °C

2.1: toluene-4-sulfonic acid / acetone / 4 h / 25 °C

3.1: ammonium formate / ethanol / 4 h / 50 °C

3.2: 0.42 h / 0 °C

With n-butyllithium; ammonium formate; toluene-4-sulfonic acid; In diethyl ether; ethanol; acetone;