N-(4-BROMOPHENYL)PROPIONAMIDE

Base Information

• Chemical Name: N-(4-BROMOPHENYL)PROPIONAMIDE
• CAS No.: 2760-35-2
• Molecular Formula: C9H10 Br N O
• Molecular Weight: 228.088
• Hs Code.: 2924299090
• Mol file: 2760-35-2.mol

Synonyms:Propionanilide,4'-bromo- (7CI,8CI); 4'-Bromopropionanilide; N-(4-Bromophenyl)propionamide; NSC404309

Chemical Property of N-(4-BROMOPHENYL)PROPIONAMIDE

Chemical Property:

• Vapor Pressure: 2.01E-05mmHg at 25°C
• Melting Point: 146-148 °C
• Boiling Point: 361.8°Cat760mmHg
• PKA: 14.25±0.70(Predicted)
• Flash Point: 172.6°C
• PSA: 29.10000
• Density: 1.469g/cm³
• LogP: 2.87060

Purity/Quality:

99% ^*data from raw suppliers

N-(4-BROMOPHENYL)PROPIONAMIDE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-BROMOPHENYL)PROPIONAMIDE

There total 10 articles about N-(4-BROMOPHENYL)PROPIONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

propionic acid (802294-64-0,79-09-4) + 4-bromo-aniline (106-40-1) → 4-bromo-2-methylacetanilide (2760-35-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/asia.201000567

Reference yield: 89.0%

propionyl chloride (79-03-8) + 4-bromo-aniline (106-40-1) → 4-bromo-2-methylacetanilide (2760-35-2)

Guidance literature:

With pyridine; In toluene; for 2h; Cooling with ice;

Reference yield: 85.0%

C17H16BrNO3 → 4-bromo-2-methylacetanilide (2760-35-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 35 ℃;

DOI:10.1016/j.tetlet.2003.09.113

upstream raw materials:

propionic acid anhydride

4-bromo-aniline

1-(4-bromo-phenyl)-propanone oxime

propionic acid

Downstream raw materials:

1-(4-bromophenyl)-4-phenylquinolin-2(1H)-one

6-bromo-2-chloro-3-methylquinoline

N-(4-((4'-(benzyloxy)phenyl)(hydroxy)-methyl)phenyl)propionamide

N-(4-(4'-(benzyloxy)benzoyl)phenyl)propionamide

Refernces

• 1、 -. "Synthetic method of CF3-containing indoline and 1,2,3,4-tetrahydroisoquinoline". Paragraph 0027; 0029; 0030; 0031; 0042. . Retrieved 2019/01/14.
• 2、 -. "INHIBITORS OF FATTY ACID AMIDE HYDROLASE". Paragraph 1036. . Retrieved 2016/01/15.