2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethylamino)ethoxy)-4-nitrobenzonitrile

Base Information

Chemical Name:2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethylamino)ethoxy)-4-nitrobenzonitrile
CAS No.:1356009-91-0
Molecular Formula:C₂₄H₂₁ClFN₅O₃
Molecular Weight:481.914
Hs Code.:

Synonyms:2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethylamino)ethoxy)-4-nitrobenzonitrile

Suppliers and Price of 2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethylamino)ethoxy)-4-nitrobenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethylamino)ethoxy)-4-nitrobenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethylamino)ethoxy)-4-nitrobenzonitrile

There total 9 articles about 2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethylamino)ethoxy)-4-nitrobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.56%

: 1263868-30-9
2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

: 1356009-62-5
2-(2-aminoethoxy)-4-nitrobenzonitrile

: 7486-35-3
tri-n-butyl(vinyl)tin

: 1356009-91-0
2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethylamino)ethoxy)-4-nitrobenzonitrile

Guidance literature:: 2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine; tri-n-butyl(vinyl)tin; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 ℃; for 2h; Inert atmosphere;

2-(2-aminoethoxy)-4-nitrobenzonitrile; In tetrahydrofuran; methanol; at 75 ℃; for 18h;

Reference yield:

: 120-92-3
cyclopentanone

: 1356009-91-0
2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethylamino)ethoxy)-4-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2.1: formic acid; dihydrogen peroxide / 20 - 50 °C

3.1: 3 h / 58 - 130 °C

4.1: ammonium hydroxide / 100 °C

5.1: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

6.2: 18 h / 75 °C

With ammonium hydroxide; formic acid; dihydrogen peroxide; N,N-dimethyl-aniline; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; toluene;

Reference yield:

: 39835-14-8
2-hydroxy-4-nitro-benzonitrile

: 1356009-91-0
2-(2-(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethylamino)ethoxy)-4-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

3.2: 18 h / 75 °C

With caesium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; toluene;