4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline

Base Information

• Chemical Name: 4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline
• CAS No.: 162012-60-4
• Molecular Formula: C₁₅H₁₀ClF₂N₃O
• Molecular Weight: 321.714
• Mol file: 162012-60-4.mol

Synonyms:4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline

Chemical Property of 4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline

There total 6 articles about 4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-chloro-7-fluoro-6-methoxyquinazoline (159768-48-6) + 3-chloro-4-fluorophenylamine (367-21-5) → 4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline (162012-60-4)

Guidance literature:

With isopropyl alcohol; Heating;

DOI:10.1016/j.tetlet.2005.08.123

Reference yield:

methyl 4-fluoro-5-methoxy-2-nitrobenzoate (159768-50-0) → 4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline (162012-60-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / hydrogen / Pd/C / ethanol / 6 h / 20 °C

2: 68 percent / acetic acid / 135 °C

3: 95 percent / SOCl₂ / 16 h / Heating

4: 91 percent / i-PrOH / Heating

With thionyl chloride; hydrogen; acetic acid; isopropyl alcohol; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.tetlet.2005.08.123

Reference yield:

4?fluoro-3-methoxybenzoic acid (82846-18-2) → 4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline (162012-60-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / H₂SO₄ / 16 h / Heating

2: 62 percent / HNO₃; H₂SO₄ / 0.5 h / 0 - 10 °C

3: 89 percent / hydrogen / Pd/C / ethanol / 6 h / 20 °C

4: 68 percent / acetic acid / 135 °C

5: 95 percent / SOCl₂ / 16 h / Heating

6: 91 percent / i-PrOH / Heating

With thionyl chloride; sulfuric acid; hydrogen; nitric acid; acetic acid; isopropyl alcohol; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.tetlet.2005.08.123

upstream raw materials:

4-chloro-7-fluoro-6-methoxyquinazoline

3-chloro-4-fluorophenylamine

7-fluoro-6-methoxyquinazolin-4-ol

2-amino-4-fluoro-5-methoxybenzoic acid methyl ester

Refernces