(2R)-allyl 5-(benzyloxycarbonylamino)-2-(10-(2,2-diphenylethyl)-2,2-dimethyl-4,11-dioxo-3,12-dioxa-5,10-diazapentadec-14-en-7-ylamino)pentanoate

Base Information

Chemical Name:(2R)-allyl 5-(benzyloxycarbonylamino)-2-(10-(2,2-diphenylethyl)-2,2-dimethyl-4,11-dioxo-3,12-dioxa-5,10-diazapentadec-14-en-7-ylamino)pentanoate
CAS No.:1185841-64-8
Molecular Formula:C₄₃H₅₆N₄O₈
Molecular Weight:756.94
Hs Code.:

Synonyms:(2R)-allyl 5-(benzyloxycarbonylamino)-2-(10-(2,2-diphenylethyl)-2,2-dimethyl-4,11-dioxo-3,12-dioxa-5,10-diazapentadec-14-en-7-ylamino)pentanoate

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Chemical Property of (2R)-allyl 5-(benzyloxycarbonylamino)-2-(10-(2,2-diphenylethyl)-2,2-dimethyl-4,11-dioxo-3,12-dioxa-5,10-diazapentadec-14-en-7-ylamino)pentanoate

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Technology Process of (2R)-allyl 5-(benzyloxycarbonylamino)-2-(10-(2,2-diphenylethyl)-2,2-dimethyl-4,11-dioxo-3,12-dioxa-5,10-diazapentadec-14-en-7-ylamino)pentanoate

There total 6 articles about (2R)-allyl 5-(benzyloxycarbonylamino)-2-(10-(2,2-diphenylethyl)-2,2-dimethyl-4,11-dioxo-3,12-dioxa-5,10-diazapentadec-14-en-7-ylamino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1185841-59-1
2,2-dimethyl-10-(2,2-diphenylethyl)-4,7,11-trioxo-3,12-dioxa-5,10-diazapentadec-14-ene

: 1185841-62-6
(R)-allyl 2-amino-5-(benzyloxycarbonylamino)pentanoate

: 1185841-64-8
(2R)-allyl 5-(benzyloxycarbonylamino)-2-(10-(2,2-diphenylethyl)-2,2-dimethyl-4,11-dioxo-3,12-dioxa-5,10-diazapentadec-14-en-7-ylamino)pentanoate

Guidance literature:: 2,2-dimethyl-10-(2,2-diphenylethyl)-4,7,11-trioxo-3,12-dioxa-5,10-diazapentadec-14-ene; (R)-allyl 2-amino-5-(benzyloxycarbonylamino)pentanoate; With sodium tris(acetoxy)borohydride; In dichloromethane; for 24h;

With acetic acid; In dichloromethane;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 121505-96-2
(2-oxobut-3-enyl)carbamic acid tert-butyl ester

: 1185841-64-8
(2R)-allyl 5-(benzyloxycarbonylamino)-2-(10-(2,2-diphenylethyl)-2,2-dimethyl-4,11-dioxo-3,12-dioxa-5,10-diazapentadec-14-en-7-ylamino)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 2 h / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 24 h

With sodium tris(acetoxy)borohydride; In dichloromethane;

Reference yield:

: 4530-20-5
BOC-glycine

: 1185841-64-8
(2R)-allyl 5-(benzyloxycarbonylamino)-2-(10-(2,2-diphenylethyl)-2,2-dimethyl-4,11-dioxo-3,12-dioxa-5,10-diazapentadec-14-en-7-ylamino)pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

2: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3: dichloromethane / 2 h / 20 °C

5: sodium tris(acetoxy)borohydride / dichloromethane / 24 h

With sodium tris(acetoxy)borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;