2,2,2-trifluoro-N-[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-acetamide
CAS No.:1350636-78-0
Molecular Formula:C₈H₁₂F₃NO₂S
Molecular Weight:243.25
Hs Code.:

Synonyms:2,2,2-trifluoro-N-[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-acetamide

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Chemical Property of 2,2,2-trifluoro-N-[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-acetamide

Chemical Property:

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Technology Process of 2,2,2-trifluoro-N-[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-acetamide

There total 2 articles about 2,2,2-trifluoro-N-[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350636-92-8
{(1R,2R,4R)-4-[(2,2,2-trifluoro-acetyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate

: 1350636-78-0
2,2,2-trifluoro-N-[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-acetamide

Guidance literature:: With hydrazine hydrate; In dichloromethane; at 15 - 25 ℃; for 2h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 2,2,2-trifluoro-N-(7-oxa-bicyclo[4.1.0]hept-3-yl)-acetamide

: 1350636-78-0
2,2,2-trifluoro-N-[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl-ammonium chloride / toluene / 30 - 45 °C / Inert atmosphere

2: hydrazine hydrate / dichloromethane / 2 h / 15 - 25 °C / Inert atmosphere

With hydrazine hydrate; tetrabutyl-ammonium chloride; In dichloromethane; toluene;

Reference yield:

: 1350636-78-0
2,2,2-trifluoro-N-[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-acetamide

: 1061337-51-6
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0.25 h / 20 - 25 °C / Inert atmosphere

1.2: 1.5 h / 20 - 25 °C

2.1: potassium carbonate; water / methanol / 5 h / 40 - 45 °C / Industry scale

2.2: 1.5 h / 0 - 25 °C / Industry scale

With water; potassium carbonate; In methanol; dichloromethane;