14-O-{(1R,2R,4R)-[(2,2,2-trifluoroacetyl)-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Base Information

Chemical Name:14-O-{(1R,2R,4R)-[(2,2,2-trifluoroacetyl)-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin
CAS No.:1350636-79-1
Molecular Formula:C₃₀H₄₄F₃NO₆S
Molecular Weight:603.744
Hs Code.:

Synonyms:14-O-{(1R,2R,4R)-[(2,2,2-trifluoroacetyl)-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Suppliers and Price of 14-O-{(1R,2R,4R)-[(2,2,2-trifluoroacetyl)-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 14-O-{(1R,2R,4R)-[(2,2,2-trifluoroacetyl)-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 14-O-{(1R,2R,4R)-[(2,2,2-trifluoroacetyl)-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

There total 5 articles about 14-O-{(1R,2R,4R)-[(2,2,2-trifluoroacetyl)-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1061337-51-6
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

: 407-25-0
trifluoroacetic anhydride

: 1350636-79-1
14-O-{(1R,2R,4R)-[(2,2,2-trifluoroacetyl)-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 31716-01-5
pleuromutilin tosylate

: 1350636-78-0
2,2,2-trifluoro-N-[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-acetamide

: 1350636-79-1
14-O-{(1R,2R,4R)-[(2,2,2-trifluoroacetyl)-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Guidance literature:: pleuromutilin tosylate; 2,2,2-trifluoro-N-[(1R,3R,4R)-3-hydroxy-4-mercapto-cyclohexyl]-acetamide; In dichloromethane; at 20 - 25 ℃; for 0.25h; Inert atmosphere;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 - 25 ℃; for 1.5h; Product distribution / selectivity;

Reference yield:

: 2,2,2-trifluoro-N-(7-oxa-bicyclo[4.1.0]hept-3-yl)-acetamide

: 1350636-79-1
14-O-{(1R,2R,4R)-[(2,2,2-trifluoroacetyl)-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl-ammonium chloride / toluene / 30 - 45 °C / Inert atmosphere

2.1: hydrazine hydrate / dichloromethane / 2 h / 15 - 25 °C / Inert atmosphere

3.1: dichloromethane / 0.25 h / 20 - 25 °C / Inert atmosphere

3.2: 1.5 h / 20 - 25 °C

With hydrazine hydrate; tetrabutyl-ammonium chloride; In dichloromethane; toluene;