Norleucine, N-acetyl-4-methyl-

Base Information

• Chemical Name: Norleucine, N-acetyl-4-methyl-
• CAS No.: 757959-97-0
• Molecular Formula: C9H17 N O3
• Molecular Weight: 187.239
• Mol file: 757959-97-0.mol

Synonyms:Norleucine, N-acetyl-4-methyl-

Chemical Property of Norleucine, N-acetyl-4-methyl-

Chemical Property:

• PSA: 69.89000
• LogP: 1.85220

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Norleucine, N-acetyl-4-methyl-

There total 5 articles about Norleucine, N-acetyl-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetamide (60-35-5) + 3,10-diethyl-3,6,10-trimethyl-4,9-dioxa-3,10-disiladodecane (105746-99-4) + 3-methyl-2-buten-1-ol (556-82-1) → N-acetylleucine (99-15-0) + 2-acetamido-4-methylhexanoic acid (757959-97-0) + 2-acetamido-5-methylhexanoic acid (5440-33-5)

Guidance literature:

With hydrogen; carbonylhydridetris(triphenylphosphine)rhodium(I); dicobalt octacarbonyl; In 1,4-dioxane; Yield given. Yields of byproduct given; 100 atm, 25 deg C and 120 deg C, 16 h, then 130 atm 2 to 3 h;

DOI:10.1016/0022-328X(86)80089-4

Reference yield:

acetamide (60-35-5) + carbon monoxide (201230-82-2) + 3-methyl-2-buten-1-ol (556-82-1) → N-acetylleucine (99-15-0) + 2-acetamido-4-methylhexanoic acid (757959-97-0) + 2-acetamido-5-methylhexanoic acid (5440-33-5)

Guidance literature:

With hydrogen; carbonylhydridetris(triphenylphosphine)rhodium(I); dicobalt octacarbonyl; In 1,4-dioxane; Product distribution; Mechanism; 100 atm, 25 deg C and 120 deg C, 16 h, then 130 atm 2 to 3 h; reactions of derivatives;

DOI:10.1016/0022-328X(86)80089-4

Reference yield:

acetamide (60-35-5) + 2-methyl-3-buten-2-ol (115-18-4) + carbon monoxide (201230-82-2) → 2-acetamido-4-methylhexanoic acid (757959-97-0) + 2-acetamido-5-methylhexanoic acid (5440-33-5)

Guidance literature:

With hydrogen; carbonylhydridetris(triphenylphosphine)rhodium(I); dicobalt octacarbonyl; In 1,4-dioxane; Yield given. Yields of byproduct given; 100 atm, 25 deg C and 120 deg C, 16 h, then 130 atm 2 to 3 h;

DOI:10.1016/0022-328X(86)80089-4

upstream raw materials:

acetamide

carbon monoxide

3-methyl-2-buten-1-ol

3,10-diethyl-3,6,10-trimethyl-4,9-dioxa-3,10-disiladodecane

Refernces