(S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine

Base Information

Chemical Name:(S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine
CAS No.:1239363-34-8
Molecular Formula:C₁₇H₁₇FN₆
Molecular Weight:324.361
Hs Code.:

(S)-N<sub>2</sub>-[1-(4-fluorophenyl)ethyl]-N<sub>6</sub>-(pyrazin-2-yl)pyridine-2,4,6-triamine

Synonyms:(S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine

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Chemical Property of (S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine

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Technology Process of (S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine

There total 4 articles about (S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1239363-34-8
(S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine

Guidance literature:: Multi-step reaction with 4 steps

1: diphenylphosphoranyl azide; triethylamine / Reflux

2: sodium t-butanolate / palladium diacetate / 1,4-dioxane / 10 h / 100 °C / Inert atmosphere

3: sodium t-butanolate; XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 100 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; sodium t-butanolate; XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; palladium diacetate; In 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 1239363-33-7
t-butyl (S)-2-[1-(4-fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)pyridin-4-yl-carbamate

: 1239363-34-8
(S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 501907-61-5
tert-butyl (2,6-dichloropyridin-4-yl)carbamate

: 1239363-34-8
(S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate / 1,4-dioxane / 10 h / 89 °C / Inert atmosphere

2: sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / toluene / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; trifluoroacetic acid; sodium t-butanolate; XPhos; In 1,4-dioxane; dichloromethane; toluene;