1H-Indazole-7-carboxylic acid

Base Information

• Chemical Name: 1H-Indazole-7-carboxylic acid
• CAS No.: 755752-82-0
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.175
• Hs Code.: 2933998090
• Mol file: 755752-82-0.mol

Synonyms:7-INDAZOLE CARBOXYLLIC ACID;Methyl indazole-7-carboxylate;1H-Indazole-7-carboxylic acid methyl ester;Methyl indazole-7-carboxy...;7-(Methoxycarbonyl)-1H-indazole;7-(1H)Indazole carboxylic acid Methyl ester

Chemical Property of 1H-Indazole-7-carboxylic acid

Chemical Property:

• Vapor Pressure: 6.24E-05mmHg at 25°C
• Refractive Index: 1.648
• Boiling Point: 345.2 °C at 760 mmHg
• PKA: 11.93±0.40(Predicted)
• Flash Point: 162.6 °C
• PSA: 54.98000
• Density: 1.324 g/cm³
• LogP: 1.34950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Methylindazole-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indazole-7-carboxylic acid

There total 12 articles about 1H-Indazole-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + 1H-indazole-7-carboxylic acid (677304-69-7) → 1H-indazole-7-carboxylic acid methyl ester (755752-82-0,952479-65-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

Reference yield: 82.0%

C9H10N2O3 → methyl 2H-indazole-7-carboxylate (755752-82-0,952479-65-1)

Guidance literature:

In methanol; at 60 ℃; for 3h;

Reference yield: 68.0%

methyl 2-amino-3-methylbenzoate (22223-49-0) → 1H-indazole-7-carboxylic acid methyl ester (755752-82-0,952479-65-1)

Guidance literature:

methyl 2-amino-3-methylbenzoate; With acetic anhydride; isopentyl nitrite; In chloroform; at -40 - 20 ℃; for 1h;

With potassium acetate; for 24h; Heating / reflux;

upstream raw materials:

methyl 2-amino-3-methylbenzoate

2-acetylamino-3-methyl-benzoic acid methyl ester

o-toluidine

2-(hydroxyimino)-N-(2-methylphenyl)acetamide

Downstream raw materials:

(1H-indazol-7-yl)methanol

1-H-indazole-7-carbaldehyde

3-iodo-1H-indazole-7-carbaldehyde

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