13-cyclohexyl-3-methoxy-6-{2-[methyl-(2-methylamino-ethyl)-amino]-ethylcarbamoyl}-7H-benzo[3,4]azepino[1,2-a]indole-10-carboxylic acid tert-butyl ester

Base Information

Chemical Name:13-cyclohexyl-3-methoxy-6-{2-[methyl-(2-methylamino-ethyl)-amino]-ethylcarbamoyl}-7H-benzo[3,4]azepino[1,2-a]indole-10-carboxylic acid tert-butyl ester
CAS No.:1204417-36-6
Molecular Formula:C₃₆H₄₈N₄O₄
Molecular Weight:600.802
Hs Code.:

13-cyclohexyl-3-methoxy-6-{2-[methyl-(2-methylamino-ethyl)-amino]-ethylcarbamoyl}-7H-benzo[3,4]azepino[1,2-a]indole-10-carboxylic acid tert-butyl ester

Synonyms:13-cyclohexyl-3-methoxy-6-{2-[methyl-(2-methylamino-ethyl)-amino]-ethylcarbamoyl}-7H-benzo[3,4]azepino[1,2-a]indole-10-carboxylic acid tert-butyl ester

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Chemical Property of 13-cyclohexyl-3-methoxy-6-{2-[methyl-(2-methylamino-ethyl)-amino]-ethylcarbamoyl}-7H-benzo[3,4]azepino[1,2-a]indole-10-carboxylic acid tert-butyl ester

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Technology Process of 13-cyclohexyl-3-methoxy-6-{2-[methyl-(2-methylamino-ethyl)-amino]-ethylcarbamoyl}-7H-benzo[3,4]azepino[1,2-a]indole-10-carboxylic acid tert-butyl ester

There total 7 articles about 13-cyclohexyl-3-methoxy-6-{2-[methyl-(2-methylamino-ethyl)-amino]-ethylcarbamoyl}-7H-benzo[3,4]azepino[1,2-a]indole-10-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204417-35-5
13-cyclohexyl-3-methoxy-6-[2-(methyl-{2-[methyl-(2-nitro-benzenesulfonyl)-amino]-ethyl}-amino)-ethylcarbamoyl]-7H-benzo[3,4]azepino[1,2-a]indole-10-carboxylic acid tert-butyl ester

: 1204417-36-6
13-cyclohexyl-3-methoxy-6-{2-[methyl-(2-methylamino-ethyl)-amino]-ethylcarbamoyl}-7H-benzo[3,4]azepino[1,2-a]indole-10-carboxylic acid tert-butyl ester

Guidance literature:: With caesium carbonate; thiophenol; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: C₄₂H₅₁N₅O₈S

: 1204417-36-6
13-cyclohexyl-3-methoxy-6-{2-[methyl-(2-methylamino-ethyl)-amino]-ethylcarbamoyl}-7H-benzo[3,4]azepino[1,2-a]indole-10-carboxylic acid tert-butyl ester

Guidance literature:: With caesium carbonate; thiophenol; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2012.04.113

Reference yield:

: 879498-90-5
1H-indole-6-carboxylic acid, 2-bromo-3-cyclohexyl-, 1,1-dimethylethyl ester

: 1204417-36-6
13-cyclohexyl-3-methoxy-6-{2-[methyl-(2-methylamino-ethyl)-amino]-ethylcarbamoyl}-7H-benzo[3,4]azepino[1,2-a]indole-10-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,2-dimethoxyethane; water / 1 h / 70 °C

2: caesium carbonate / N,N-dimethyl-formamide / 60 °C

3: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran

5: caesium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; water; potassium carbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; thiophenol; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.04.113