1-benzyl-4-methyl-α,9-dioxo-4,9-dihydro-1H-imidazo[1,2-a]purin-7-ethanoic acid methyl ester

Base Information

Chemical Name:1-benzyl-4-methyl-α,9-dioxo-4,9-dihydro-1H-imidazo[1,2-a]purin-7-ethanoic acid methyl ester
CAS No.:252272-03-0
Molecular Formula:C₁₈H₁₅N₅O₄
Molecular Weight:365.348
Hs Code.:

Synonyms:1-benzyl-4-methyl-α,9-dioxo-4,9-dihydro-1H-imidazo[1,2-a]purin-7-ethanoic acid methyl ester

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Chemical Property of 1-benzyl-4-methyl-α,9-dioxo-4,9-dihydro-1H-imidazo[1,2-a]purin-7-ethanoic acid methyl ester

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Technology Process of 1-benzyl-4-methyl-α,9-dioxo-4,9-dihydro-1H-imidazo[1,2-a]purin-7-ethanoic acid methyl ester

There total 2 articles about 1-benzyl-4-methyl-α,9-dioxo-4,9-dihydro-1H-imidazo[1,2-a]purin-7-ethanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 67-56-1
methanol

: 79-37-8
oxalyl dichloride

: 252271-84-4
1-benzyl-4-methyl-4,9-dihydro-1H-imidazo[1,2-a]purin-9-one

: 252272-03-0
1-benzyl-4-methyl-α,9-dioxo-4,9-dihydro-1H-imidazo[1,2-a]purin-7-ethanoic acid methyl ester

Guidance literature:: oxalyl dichloride; 1-benzyl-4-methyl-4,9-dihydro-1H-imidazo[1,2-a]purin-9-one; With triethylamine; In tetrahydrofuran; at 20 ℃; for 5h;

methanol; In tetrahydrofuran; at 20 ℃; for 0.25h;
DOI:10.1248/cpb.47.1464

Reference yield:

: 65120-78-7
7-benzyl-3-methylguanine

: 252272-03-0
1-benzyl-4-methyl-α,9-dioxo-4,9-dihydro-1H-imidazo[1,2-a]purin-7-ethanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / AcONa; AcOH / ethanol / 24 h / 37 - 40 °C / pH 6

2.1: Et₃N / tetrahydrofuran / 5 h / 20 °C

2.2: 67 percent / tetrahydrofuran / 0.25 h / 20 °C

With sodium acetate; acetic acid; triethylamine; In tetrahydrofuran; ethanol; 1.1: Cyclization / 2.1: Acylation / 2.2: methanolysis;
DOI:10.1248/cpb.47.1464