(S)-2-trimethylsiloxy-2-phenyl propionitrile

Base Information

• Chemical Name: (S)-2-trimethylsiloxy-2-phenyl propionitrile
• CAS No.: 252966-52-2
• Molecular Formula: C₁₂H₁₇NOSi
• Molecular Weight: 219.359
• Mol file: 252966-52-2.mol

Synonyms:(S)-2-trimethylsiloxy-2-phenyl propionitrile

Chemical Property of (S)-2-trimethylsiloxy-2-phenyl propionitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-2-trimethylsiloxy-2-phenyl propionitrile

There total 4 articles about (S)-2-trimethylsiloxy-2-phenyl propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trimethylsilyl cyanide (7677-24-9) + acetophenone (98-86-2) → (S)-2-trimethylsiloxy-2-phenyl propionitrile (252966-52-2)

Guidance literature:

With titanium(IV) isopropylate; 3,3'-di-α-naphthyl biphenol; cinchonine; In hexane; at -20 ℃; for 20h; optical yield given as %ee; Inert atmosphere;

DOI:10.1002/chem.200900936

Reference yield: 96.0%

trimethylsilyl cyanide (7677-24-9) + (S)-2-(hydroxy)-2-phenyl-propanonitrile (174849-24-2) → (S)-2-trimethylsiloxy-2-phenyl propionitrile (252966-52-2)

Guidance literature:

With n-butyllithium; (11bR)-4-(2-hydroxyphenyl)-2,6-diphenyldinaphtho[2,1-d:1’,2’-f][1,3,2]dioxaphosphepine-4-oxide; In water; toluene; at -78 ℃; for 0.0166667h; enantioselective reaction;

DOI:10.1002/anie.201510682

Reference yield:

trimethylsilyl cyanide (7677-24-9) + acetophenone (98-86-2) → (R)-2-trimethylsilyloxy-2-phenylpropanenitrile + (S)-2-trimethylsiloxy-2-phenyl propionitrile (252966-52-2)

Guidance literature:

With bimetallic chiral (salen)titanium(IV); In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/S0040-4039(99)01677-9

upstream raw materials:

trimethylsilyl cyanide

acetophenone

N,O-Bis(trimethylsilyl)trifluoroacetamide

(S)-2-(hydroxy)-2-phenyl-propanonitrile

Downstream raw materials:

(S)-2-(hydroxy)-2-phenyl-propanonitrile