(S)-2-(hydroxy)-2-phenyl-propanonitrile

Base Information

• Chemical Name: (S)-2-(hydroxy)-2-phenyl-propanonitrile
• CAS No.: 174849-24-2
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.177
• Mol file: 174849-24-2.mol

Synonyms:(S)-2-(hydroxy)-2-phenyl-propanonitrile

Chemical Property of (S)-2-(hydroxy)-2-phenyl-propanonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(hydroxy)-2-phenyl-propanonitrile

There total 7 articles about (S)-2-(hydroxy)-2-phenyl-propanonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(S)-2-trimethylsiloxy-2-phenyl propionitrile (252966-52-2) → (S)-2-(hydroxy)-2-phenyl-propanonitrile (174849-24-2)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(00)01053-X

Reference yield: 40.0%

hydrogen cyanide (74-90-8) + acetophenone (98-86-2) → (S)-2-(hydroxy)-2-phenyl-propanonitrile (174849-24-2)

Guidance literature:

With hydroxynitrile lyase from Hevea brasiliensis; sodium citrate; In di-isopropyl ether; water; at 0 ℃; pH 3.75;

DOI:10.1016/S0040-4020(98)00901-6

Reference yield:

acetophenone (98-86-2) → (S)-2-(hydroxy)-2-phenyl-propanonitrile (174849-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: [{3,5-di-tBu-salicylidene-(R,R)-1,2-cyclohexanediamine}TiO]2 / CH₂Cl₂ / 23 °C

2: 85 percent / aq. HCl / 2 h / 20 °C

With hydrogenchloride; di-μ-oxo-di((R,R)-N,N'-bis((alicylaldehydo)ethylenediamine))dititanium(IV); In dichloromethane;

DOI:10.1016/S0040-4020(00)01053-X

upstream raw materials:

hydrogen cyanide

acetophenone

2-hydroxy-2-phenylpropionitrile

trimethylsilyl cyanide

Downstream raw materials:

(S)-2-trimethylsiloxy-2-phenyl propionitrile

(S)-1-cyano-1-phenylethyl (S)-2-methoxy-2-phenylacetate

(S)-1-cyano-1-phenylethyl (R)-2-methoxy-2-phenylacetate

C₉H₇NO₃