tert-butyl 4-<3-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)propyl>benzoate

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Chemical Name:tert-butyl 4-<3-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)propyl>benzoate
CAS No.:126016-77-1
Molecular Formula:C₂₀H₂₅N₅O₃
Molecular Weight:383.45
Hs Code.:

Synonyms:tert-butyl 4-<3-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)propyl>benzoate

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Chemical Property of tert-butyl 4-<3-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)propyl>benzoate

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Technology Process of tert-butyl 4-<3-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)propyl>benzoate

There total 6 articles about tert-butyl 4-<3-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)propyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 50-01-1
guanidine hydrochloride

: 130351-33-6
ethyl 5-<4-(tert-butoxycarbonyl)phenyl>-2-(dicyanomethyl)pentanoate

: 126016-77-1
tert-butyl 4-<3-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)propyl>benzoate

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; for 4h; Heating;
DOI:10.1021/jm00106a012

Reference yield:

: 125991-38-0
methyl 5-[4-(tert-butoxycarbonyl)-phenyl]-2-(dicyanomethyl)pentanoate

: 50-01-1
guanidine hydrochloride

: 113-00-8
guanidine nitrate

: 126016-77-1
tert-butyl 4-<3-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)propyl>benzoate

Guidance literature:: With potassium hydrogen sulphate; potassium tert-butylate; ammonia; In funnel-ethanol; dichloromethane; water; tert-butyl alcohol;

Reference yield:

: 65874-27-3
4-(tert-butoxycarbonyl)benzaldehyde

: 126016-77-1
tert-butyl 4-<3-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)propyl>benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: t-BuOK / 2-methyl-propan-2-ol; diethyl ether / 2 h / 12 °C

2: 1.) H₂, 2.) 4-(N,N-dimethylamino)pyridine (DMAP), dicyclohexylcarbodiimide (DCC) / 1.) 5percent Pd/C / 1.) AcOEt, 4 at, 3 h, 2.) EtOH-CH₂Cl₂, 20 deg C, 18 h

3: 1.) LDA, 2.) I₂ / 1.) hexane, THF, -78 deg C, 10 min, 2.) a) -78 deg C, 20 min, b) from -78 deg C to 0 deg C, 30 min

4: 1.) NaH / 1.) Me₂SO, RT, 5 min, 2.) 20 deg C, 1 h

5: 89 percent / t-BuOK / 2-methyl-propan-2-ol / 4 h / Heating

With dmap; potassium tert-butylate; hydrogen; iodine; sodium hydride; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In diethyl ether; tert-butyl alcohol;
DOI:10.1021/jm00106a012