4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-methyl-benzo[d]imidazole-7yl) oxazole

Base Information

• Chemical Name: 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-methyl-benzo[d]imidazole-7yl) oxazole
• CAS No.: 1403581-31-6
• Molecular Formula: C₂₁H₂₁N₃O₅
• Molecular Weight: 395.415

Synonyms:4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-methyl-benzo[d]imidazole-7yl) oxazole

Chemical Property of 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-methyl-benzo[d]imidazole-7yl) oxazole

Chemical Property:

Purity/Quality:

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Technology Process of 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-methyl-benzo[d]imidazole-7yl) oxazole

There total 3 articles about 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N¹-methyl-benzo[d]imidazole-7yl) oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.8%

4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-1H-benzo[d]imidazole-7-yl) oxazole (1403581-29-2) + methyl iodide (74-88-4) → 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N1-methylbenzo[d]imidazole-4yl)oxazole (1403581-32-7) + 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N1-methyl-benzo[d]imidazole-7yl) oxazole (1403581-31-6)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Reflux;

DOI:10.1016/j.ejmech.2013.08.006

Reference yield:

4-methoxy-7-carbaldehyde-N1-1H-benzo[d]imidazole (1403581-61-2) → 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N1-methylbenzo[d]imidazole-4yl)oxazole (1403581-32-7) + 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N1-methyl-benzo[d]imidazole-7yl) oxazole (1403581-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 25 h / 20 °C / Reflux

2: potassium carbonate / acetone / 24 h / Reflux

With potassium carbonate; In methanol; acetone;

DOI:10.1016/j.ejmech.2013.08.006

Reference yield:

2-Amino-3-nitrophenol (603-85-0) → 4-(3,4,5-trimethoxyphenyl)-5-(7-methoxy-N1-methylbenzo[d]imidazole-4yl)oxazole (1403581-32-7) + 4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-N1-methyl-benzo[d]imidazole-7yl) oxazole (1403581-31-6)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C

2: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 20 °C

3: 4 h / Reflux

4: trifluoroacetic acid / 36 h / Reflux

5: potassium carbonate / methanol / 25 h / 20 °C / Reflux

6: potassium carbonate / acetone / 24 h / Reflux

With palladium 10% on activated carbon; hydrogen; potassium carbonate; trifluoroacetic acid; In methanol; ethanol; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.ejmech.2013.08.006

upstream raw materials:

4-methoxy-7-carbaldehyde-N¹-1H-benzo[d]imidazole

4-(3,4,5-trimethoxyphenyl)-5-(4-methoxy-1H-benzo[d]imidazole-7-yl) oxazole

methyl iodide

2-Amino-3-nitrophenol

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