Methyl 4-chloro-alpha-(dimethoxyphosphinyl)benzeneacetate

Base Information

• Chemical Name: Methyl 4-chloro-alpha-(dimethoxyphosphinyl)benzeneacetate
• CAS No.: 154702-26-8
• Molecular Formula: C₁₁H₁₄ClO₅P
• Molecular Weight: 292.656
• DSSTox Substance ID: DTXSID101215928

Synonyms:154702-26-8;DTXSID101215928;Methyl 2-(4-chlorophenyl)-2-(dimethoxyphosphoryl)acetate

Chemical Property of Methyl 4-chloro-alpha-(dimethoxyphosphinyl)benzeneacetate

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 292.0267382
• Heavy Atom Count: 18
• Complexity: 319

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC(=O)C(C1=CC=C(C=C1)Cl)P(=O)(OC)OC

Technology Process of Methyl 4-chloro-alpha-(dimethoxyphosphinyl)benzeneacetate

There total 1 articles about Methyl 4-chloro-alpha-(dimethoxyphosphinyl)benzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

p-Chlorobenzylphosphonsaeuredimethylester (58358-45-5) + methyl chloroformate (79-22-1) → methyl dimethoxyphosphoryl(4-chlorophenyl)acetate (154702-26-8)

Guidance literature:

With n-butyllithium; triphenylmethane; In diethyl ether; at -78 ℃;

DOI:10.1016/0040-4039(94)88430-7

Reference yield:

2,6-dichlorobenzaldehyde (83-38-5) + methyl dimethoxyphosphoryl(4-chlorophenyl)acetate (154702-26-8) → (E)-2-(4-Chloro-phenyl)-3-(2,6-dichloro-phenyl)-acrylic acid methyl ester

Guidance literature:

With sodium methylate; Yield given. Multistep reaction; 1.) CH₃OH, RT, 0.5 h. 2) CH₃OH, RT, overnight;

Reference yield:

benzaldehyde (100-52-7) + methyl dimethoxyphosphoryl(4-chlorophenyl)acetate (154702-26-8) → methyl (Z)-2-(4-chlorophenyl)-3-phenylprop-2-enoate (151358-36-0)

Guidance literature:

With sodium methylate; Yield given. Multistep reaction; 1.) CH₃OH, RT, 0.5 h. 2) CH₃OH, RT, overnight;

upstream raw materials:

p-Chlorobenzylphosphonsaeuredimethylester

methyl chloroformate

Downstream raw materials:

methyl (Z)-2-(4-chlorophenyl)-3-phenylprop-2-enoate

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