4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Base Information

Chemical Name:4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
CAS No.:10179-57-4
Molecular Formula:C₂₁H₁₉N₃O₂S
Molecular Weight:377.467
Hs Code.:

Synonyms:4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Suppliers and Price of 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
MLS-573151 99.74%
100mg
$ 950.00

ChemScene
MLS-573151 99.74%
50mg
$ 550.00

ChemScene
MLS-573151 99.74%
10mg
$ 170.00

ChemScene
MLS-573151 99.74%
5mg
$ 100.00

ChemScene
MLS-573151 99.74%
25mg
$ 350.00

Cayman Chemical
MLS-573151 ≥98%
25mg
$ 350.00

Cayman Chemical
MLS-573151 ≥98%
5mg
$ 95.00

Cayman Chemical
MLS-573151 ≥98%
1mg
$ 35.00

Cayman Chemical
MLS-573151 ≥98%
10mg
$ 165.00

ApexBio Technology
MLS-573151
5mg
$ 131.00

Total 8 raw suppliers

Chemical Property of 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

MLS-573151 99.74% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM). It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. It acts by blocking the binding of GTP to Cdc42.
Uses The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. MLS-573151 is a specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM). It has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. It acts by blocking the binding of GTP to Cdc42.[Cayman Chemical]

Technology Process of 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

There total 6 articles about 4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride

: 94-41-7
benzalacetophenone

: 10179-57-4
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Guidance literature:: With acetic acid; In ethanol; for 12h; Reflux;
DOI:10.1080/14756366.2016.1244533

Reference yield: 70.0%

: 94-41-7
benzalacetophenone

: 4392-54-5
4-aminosulfonylphenylhydrazine

: 10179-57-4
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Guidance literature:: In ethanol; for 3h; Heating;

Reference yield:

: 100-52-7
benzaldehyde

: 98-86-2
acetophenone

: 10179-57-4
4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: barium hydroxide octahydrate / ethanol / 30 °C

2: potassium hydroxide / ethanol / 24 h / 120 °C

With barium hydroxide octahydrate; potassium hydroxide; In ethanol; 1: |Claisen-Schmidt Condensation;
DOI:10.1016/j.ejmech.2017.09.060