1-(6-Bromopyridin-2-YL)-N,N-dimethylmethanamine

Base Information

• Chemical Name: 1-(6-Bromopyridin-2-YL)-N,N-dimethylmethanamine
• CAS No.: 83004-11-9
• Molecular Formula: C8H11 Br N2
• Molecular Weight: 215.09000
• DSSTox Substance ID: DTXSID10513838
• Wikidata: Q82373843
• Mol file: 83004-11-9.mol

Synonyms:83004-11-9;1-(6-BROMOPYRIDIN-2-YL)-N,N-DIMETHYLMETHANAMINE;2-Pyridinemethanamine,6-bromo-N,N-dimethyl-;SCHEMBL5846680;DTXSID10513838;XHYBZNLPYKVONJ-UHFFFAOYSA-N;AKOS015835975;(6-Bromopyridin-2-ylmethyl)dimethylamine;1-(6-bromo-2-pyridyl)-N,N-dimethyl-methanamine;A840485

Chemical Property of 1-(6-Bromopyridin-2-YL)-N,N-dimethylmethanamine

Chemical Property:

• PSA: 16.13000
• LogP: 1.90570
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 214.01056
• Heavy Atom Count: 11
• Complexity: 117

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC1=NC(=CC=C1)Br

Technology Process of 1-(6-Bromopyridin-2-YL)-N,N-dimethylmethanamine

There total 4 articles about 1-(6-Bromopyridin-2-YL)-N,N-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

6-bromo-2-pyridinecarbaldehyde (34160-40-2) + dimethyl amine (124-40-3) → 1-(6-bromopyridin-2-yl)-N,N-dimethylmethanamine (83004-11-9)

Guidance literature:

6-bromo-2-pyridinecarbaldehyde; dimethyl amine; In tetrahydrofuran; 1,2-dichloro-ethane; at 20 ℃; for 0.0833333h; Inert atmosphere; Schlenk technique;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.organomet.6b00009

Reference yield:

6-bromo-2-pyridinecarbaldehyde (34160-40-2) + N,N-dimethylammonium chloride (506-59-2) → 1-(6-bromopyridin-2-yl)-N,N-dimethylmethanamine (83004-11-9)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 18h; Molecular sieve;

Reference yield:

2-bromo-6-bromomethylpyridine (83004-10-8) + dimethyl amine (124-40-3) → 1-(6-bromopyridin-2-yl)-N,N-dimethylmethanamine (83004-11-9)

Guidance literature:

at 60 ℃; for 6h;

upstream raw materials:

2-bromo-6-bromomethylpyridine

dimethyl amine

6-bromo-2-pyridinecarbaldehyde

N,N-dimethylammonium chloride