carbonic acid 4-tert-butoxycarbonyloxy-3-formyl-phenyl ester tert-butyl ester

Base Information

• Chemical Name: carbonic acid 4-tert-butoxycarbonyloxy-3-formyl-phenyl ester tert-butyl ester
• CAS No.: 346433-43-0
• Molecular Formula: C₁₇H₂₂O₇
• Molecular Weight: 338.357
• Mol file: 346433-43-0.mol

Synonyms:carbonic acid 4-tert-butoxycarbonyloxy-3-formyl-phenyl ester tert-butyl ester

Chemical Property of carbonic acid 4-tert-butoxycarbonyloxy-3-formyl-phenyl ester tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of carbonic acid 4-tert-butoxycarbonyloxy-3-formyl-phenyl ester tert-butyl ester

There total 1 articles about carbonic acid 4-tert-butoxycarbonyloxy-3-formyl-phenyl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,5-Dihydroxybenzaldehyde (1194-98-5) + di-tert-butyl dicarbonate (24424-99-5) → carbonic acid 4-tert-butoxycarbonyloxy-3-formyl-phenyl ester tert-butyl ester (346433-43-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jo001752e

Reference yield: 86.0%

methylmagnesium chloride (676-58-4) + carbonic acid 4-tert-butoxycarbonyloxy-3-formyl-phenyl ester tert-butyl ester (346433-43-0) → carbonic acid tert-butyl ester 4-hydroxy-3-isopropyl-phenyl ester

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1021/jo001752e

Reference yield: 65.0%

vinyl magnesium bromide (1826-67-1) + methyllithium (917-54-4) + carbonic acid 4-tert-butoxycarbonyloxy-3-formyl-phenyl ester tert-butyl ester (346433-43-0) → carbonic acid tert-butyl ester 4-hydroxy-3-(1-methyl-allyl)-phenyl ester

Guidance literature:

methyllithium; carbonic acid 4-tert-butoxycarbonyloxy-3-formyl-phenyl ester tert-butyl ester; In tetrahydrofuran; at -78 ℃; for 0.416667h;

vinyl magnesium bromide; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo001752e

upstream raw materials:

2,5-Dihydroxybenzaldehyde

di-tert-butyl dicarbonate

Downstream raw materials:

carbonic acid tert-butyl ester 4-hydroxy-3-(3-methyl-but-2-enyl)-phenyl ester

Refernces

• 1、 Jones,Van De Water,Lindsey,Hoarau,Ung,Pettus. "A mild anionic method for generating o-quinone methides: Facile preparations of ortho-functionalized phenols". . p. 3435 - 3441. Retrieved 2007/10/03.