[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-ylmethyl]dimethylamine

Base Information

• Chemical Name: [2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-ylmethyl]dimethylamine
• CAS No.: 887645-49-0
• Molecular Formula: C₂₁H₂₀FN₅S
• Molecular Weight: 393.488

Synonyms:[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-ylmethyl]dimethylamine

Chemical Property of [2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-ylmethyl]dimethylamine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of [2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-ylmethyl]dimethylamine

There total 6 articles about [2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-ylmethyl]dimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanesulfonic acid [2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]methyl ester (762172-92-9) + dimethyl amine (124-40-3) → [2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-ylmethyl]dimethylamine (887645-49-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile; for 0.25h;

DOI:10.1016/j.ejmech.2007.02.006

Reference yield:

2-methylthio-4-methylpyrimidine (14001-63-9) → [2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-ylmethyl]dimethylamine (887645-49-0)

Guidance literature:

Multi-step reaction with 5 steps

1: lithium diisopropylamide / tetrahydrofuran

2: tetra-n-butylammonium tribromide / CH₂Cl₂

3: ethanol / Heating

4: Et₃N

5: i-Pr₂NEt

With tetra-N-butylammonium tribromide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.01.092

Reference yield:

methyl 4-flurobenzoate (403-33-8) → [2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-ylmethyl]dimethylamine (887645-49-0)

Guidance literature:

Multi-step reaction with 5 steps

1: lithium diisopropylamide / tetrahydrofuran

2: tetra-n-butylammonium tribromide / CH₂Cl₂

3: ethanol / Heating

4: Et₃N

5: i-Pr₂NEt

With tetra-N-butylammonium tribromide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2006.01.092

upstream raw materials:

methanesulfonic acid [2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]methyl ester

dimethyl amine

[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]methanol

2-methylthio-4-methylpyrimidine

Downstream raw materials:

4-[7-[(dimethylamino)methyl]-2-(4-fluorphenyl)imidazo[1,2-α]pyridine-3-yl]pyrimidin-2-amine

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