2,6-diamino-4-(thiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Base Information

• Chemical Name: 2,6-diamino-4-(thiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile
• CAS No.: 127118-65-4
• Molecular Formula: C₁₁H₈N₄S₂
• Molecular Weight: 260.343
• Mol file: 127118-65-4.mol

Synonyms:2,6-diamino-4-(thiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Chemical Property of 2,6-diamino-4-(thiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Chemical Property:

• Melting Point: 162-165 °C
• Boiling Point: 637.8±55.0 °C(Predicted)
• PKA: 2.29±0.70(Predicted)
• Density: 1.51±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2,6-Diamino-4-(2-thienyl)-4H-thiopyran-3,5-dicarbonitrile ^*data from reagent suppliers

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Technology Process of 2,6-diamino-4-(thiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

There total 4 articles about 2,6-diamino-4-(thiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

thiophene-2-carbaldehyde (98-03-3) + propylamine (107-10-8,42939-71-9) + carbon disulfide (75-15-0,12122-00-8) + malononitrile (109-77-3) → 2,6-diamino-4-(thiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile (127118-65-4)

Guidance literature:

With bis(4-pyridylamino)triazine-stabilized silica-coated magnetite nanoparticles; In ethanol; at 20 ℃; for 0.25h; Green chemistry;

DOI:10.1002/aoc.3557

Reference yield: 80.0%

thiophene-2-carbaldehyde (98-03-3) + malononitrile (109-77-3) → 2,6-diamino-4-(thiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile (127118-65-4)

Guidance literature:

malononitrile; With hydrogen sulfide; triethylamine; In ethanol; at 10 ℃;

thiophene-2-carbaldehyde; In ethanol; at 20 ℃;

DOI:10.1134/S1070428018100019

Reference yield: 79.0%

Cyanothioacetamide (7357-70-2) + 2-(2-thienyl)-1-cyanoacrylonitrile (28162-32-5) → 2,6-diamino-4-(thiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile (127118-65-4)

Guidance literature:

With 4-methyl-morpholine; In ethanol; at 25 ℃; for 4h;

DOI:10.1007/BF00961252

upstream raw materials:

Cyanothioacetamide

2-(2-thienyl)-1-cyanoacrylonitrile

2-cyano-3-(2-thienyl)-2-propenethioamide

malononitrile

Downstream raw materials:

4-(4-nitrophenyl)-2-(2-oxo-2H-chromen-3-ylcarbonylmethylsulfanyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

3-(4-bromophenyl)-2,2-pentamethylene-11-(2-thienyl)-1,2,3,4,7,8,9,10-octahydropyrimido[4',5':4,5]thieno[2,3-b]quinolin-4-one

3-amino-N-(4-bromophenyl)-4-(2-thienyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

(E)-2-[4-(4-Methoxy-phenyl)-thiazol-2-yl]-3-thiophen-2-yl-acrylonitrile

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