Technology Process of (2R,3R)-ethyl 3-azido-3-phenyl-2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)propanoate
There total 3 articles about (2R,3R)-ethyl 3-azido-3-phenyl-2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)propanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2R,3R)-3-azido-3-phenyl-2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)propanal;
With
sodium chlorite; potassium dihydrogenphosphate; dihydrogen peroxide;
In
water; acetonitrile;
at 20 ℃;
Cooling with ice;
ethanol;
With
dmap; dicyclohexyl-carbodiimide;
In
water; acetonitrile;
at 20 ℃;
for 3h;
DOI:10.1002/ejoc.201301915
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether; iron(III) chloride hexahydrate; benzoic acid / acetonitrile / 20 h / -15 °C / Green chemistry
2.1: potassium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / acetonitrile; water / 20 °C / Cooling with ice
2.2: 3 h / 20 °C
With
sodium chlorite; potassium dihydrogenphosphate; iron(III) chloride hexahydrate; (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether; dihydrogen peroxide; benzoic acid;
In
water; acetonitrile;
DOI:10.1002/ejoc.201301915
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether; iron(III) chloride hexahydrate; benzoic acid / acetonitrile / 20 h / -15 °C / Green chemistry
2.1: potassium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / acetonitrile; water / 20 °C / Cooling with ice
2.2: 3 h / 20 °C
With
sodium chlorite; potassium dihydrogenphosphate; iron(III) chloride hexahydrate; (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether; dihydrogen peroxide; benzoic acid;
In
water; acetonitrile;
DOI:10.1002/ejoc.201301915
